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JAEA Reports

Estimation methods of blood boron concentration and error evaluation during boron neutron capture therapy for malignant brain tumor

Shibata, Yasushi*; Yamamoto, Kazuyoshi; Matsumura, Akira*; Yamamoto, Tetsuya*; Hori, Naohiko; Kishi, Toshiaki; Kumada, Hiroaki; Akutsu, Hiroyoshi*; Yasuda, Susumu*; Nakai, Kei*; et al.

JAERI-Research 2005-009, 41 Pages, 2005/03

JAERI-Research-2005-009.pdf:1.99MB

The measurement of neutron flux and boron concentration in the blood during medical irradiation is indispensable in order to evaluate the radiation in boron neutron capture therapy. It is, however, difficult to measure the blood boron concentration during neutron irradiation because access to the patient is limited. Therefore we prospectively investigated the predictability of blood boron concentrations using the data obtained at the first craniotomy after infusion of a low dosage of BSH. When the test could not be carried out, the blood boron concentration during irradiation was also predicted by using the 2-compartment model. If the final boron concentration after the end of the infusion is within 95% confidence interval of the prediction, direct prediction from biexponential fit will reduce the error of blood boron concentrations during irradiation to around 6%. If the final boron concentration at 6 or 9 hours after the end of infusion is out of 95% confidence interval of the prediction, proportional adjustment will reduce error and expected error after adjustment to around 12%.

Journal Articles

The Prediction of Boron concentrations in blood for patients of boron neutron capture therapy, 2

Shibata, Yasushi*; Matsumura, Akira*; Yamamoto, Tetsuya*; Akutsu, Hiroyoshi*; Yasuda, Susumu*; Nakai, Kei*; Nose, Tadao*; Yamamoto, Kazuyoshi; Kumada, Hiroaki; Hori, Naohiko; et al.

Research and Development in Neutron Capture Therapy, p.1055 - 1060, 2002/09

We prospectively investigated the predictability of blood boron concentrations using the data obtained at the first craniotomy after infusion of a low dose of sodium undecahydroclosododecaborate (BSH). Nine patients with malignant glial tumors underwent Boron neutron capture therapy (BNCT) at the Japan Atomic Energy Research Institute (JAERI) between 1995 and 2001. In 7 patients, 1g of BSH was infused before the first tumor removal and boron concentrations were determined using prompt gamma ray analysis (PGA). Then, 12 hours before BNCT, patients were infused at a dose of 100mg/kg BSH, and the boron concentrations were determined again. The boron biodistribution data showed a biexponential pharmacokinetic profile. If the final boron concentration at 6 or 9 hours after the end of the infusion is within the 95% confidence interval of the prediction, direct prediction from biexponential fit will reduce the error of blood boron concentrations during irradiation to around 6%.

Journal Articles

Intraoperative boron neutron capture therapy using thermal/epithermal mixed beam

Matsumura, Akira*; Yamamoto, Tetsuya*; Shibata, Yasushi*; Nakai, Kei*; Zhang, T.*; Matsushita, Akira*; Takano, Shingo*; Endo, Kiyoshi*; Akutsu, Hiroyoshi*; Yamamoto, Kazuyoshi; et al.

Research and Development in Neutron Capture Therapy, p.1073 - 1078, 2002/09

Since 1998 to 2002, a new clinical trial of an intraoperative boron neutron capture therapy (IOBNCT) at JRR-4 of Japan Atomic Energy Institute (JAERI) using BSH with mixed thermal/epithermal neutron beam has been accomplished. There have been 9 patients included in this study. The median survival time (MST) in GBM was 19.8 months and 16.8 months in AA. IOBNCT with mixed thermal/epithermal neutron beam provide better primary radiation effect than conventional therapy in selected cases. Our phase I/II clinical trial was effective in local tumor control. Further clinical trial with new design should be performed to prove the efficacy of IOBNCT.

Journal Articles

Failure pattern in the patients who underwent intraoperative boron neutron capture therapy (IOBNCT)

Nakai, Kei*; Matsumura, Akira*; Yamamoto, Tetsuya*; Shibata, Yasushi*; Zhang, T.*; Akutsu, Hiroyoshi*; Matsuda, M.*; Matsushita, Akira*; Yasuda, Susumu*; Takano, Shingo*; et al.

Research and Development in Neutron Capture Therapy, p.1135 - 1138, 2002/09

7 patients have been undergoing Intraoperative boron neutron capture therapy (IOBNCT) for malignant glioma at Japan Atomic Energy Institute (JAERI). Post-BNCT MRI studies revealed one local recurrence and two distant recurrences. Distant recurrence is uncommon in the conventional radiation therapy. Symptomatic late radiation necrosis occurred in one case.

Journal Articles

Phase I/II clinical trial of boron neutron capture therapy using mixed thermal/epithermal neutron beam

Matsumura, Akira*; Yamamoto, Tetsuya*; Shibata, Yasushi*; Nakai, Kei*; Zhang, T.*; Akutsu, Hiroyoshi*; Matsushita, Akira*; Yasuda, Susumu*; Takano, Shingo*; Nose, Tadao*; et al.

Posuto Shikuensu Jidai Ni Okeru Noshuyo No Kenkyu To Chiryo, p.427 - 435, 2002/07

no abstracts in English

Journal Articles

Basic and clinical studies for application of epithermal neutron beam for neutron capture therapy

Nose, Tadao*; Matsumura, Akira*; Yamamoto, Tetsuya*; Shibata, Yasushi*; Yoshida, Fumiyo*; Akutsu, Hiroyoshi*; Yasuda, Susumu*; Matsushita, Akira*; Nakai, Kei*; Yamada, Takashi*; et al.

UTRCN-G-29, p.114 - 123, 2001/00

no abstracts in English

Journal Articles

Intraoperative boron neturon capture therapy for malignant gliomas; First clinical results of Tsukuba phase I/II trial using JAERI mixed thermal-epithermal beam

Matsumura, Akira*; Yamamoto, Tetsuya*; Shibata, Yasushi*; Akutsu, Hiroyoshi*; Yasuda, Susumu*; Matsushita, Akira*; Nakai, K.*; Yamada, Takashi*; Takano, Shingo*; Mizutani, Taro*; et al.

Proceedings of 9th International Symposium on Neutron Capture Therapy for Cancer, p.29 - 30, 2000/10

no abstracts in English

Journal Articles

Optimization of intraoperative (IO)BNCT; Pre-irradiation surgical technique and 2-D dosimetry in surgical field

Yasuda, Susumu*; Yamamoto, Tetsuya*; Matsumura, Akira*; Shibata, Yasushi*; Akutsu, Hiroyoshi*; Matsushita, Akira*; Nakai, K.*; Nose, Tadao*; Yamamoto, Kazuyoshi; Kumada, Hiroaki; et al.

Proceedings of 9th International Symposium on Neutron Capture Therapy for Cancer, p.171 - 172, 2000/10

no abstracts in English

Journal Articles

Prediction of boron concentration in blood from low dose infusion for the patients of BNCT at JAERI

Shibata, Yasushi*; Matsumura, Akira*; Yamamoto, Tetsuya*; Akutsu, Hiroyoshi*; Yasuda, Susumu*; Nakai, K.*; Nose, Tadao*; Yamamoto, Kazuyoshi; Kumada, Hiroaki; Hori, Naohiko; et al.

Proceedings of 9th International Symposium on Neutron Capture Therapy for Cancer, p.145 - 146, 2000/10

no abstracts in English

Oral presentation

The New laser-irradiating fiberscope system for hemostasis in the treatment of intracranial lesions

Oka, Kiyoshi; Seki, Takeshi; Akatsu, Tomohiro; Akutsu, Hiroyoshi*; Yamamoto, Tetsuya*; Ihara, Satoshi*; Watanabe, Shinya*; Matsumura, Akira*; Kikuta, Kenichiro*

no journal, , 

For the neuroendoscopic surgery, we are developing a new laser-irradiating fiberscope system. In this system, we use a composite-type optical fiberscope (COF) with 1 mm in outer diameter, which can transmit both laser energy and images for observation simultaneously. The diameter of the cautery laser fiber is 0.1 mm, which is located in the center of the imaging fibers. In this animal experimental study, we conducted the laser-irradiation on the femoral artery and vein of a rat using a usual single core fiber of 0.1 mm in outer diameter and the COF in order to assess the availability of this system. As a result, the blood flow decreased to 1/2 or 1/3 after a cauterization with the single core fiber. Furthermore, in the laser irradiation with the COF, the contraction of the artery with minimal heat damage of adjacent tissue was confirmed. Under direct observation with optical fiberscope, the obliteration of arteries was safely and successfully performed.

Oral presentation

Medical application of composite-type optical fiberscope

Oka, Kiyoshi; Seki, Takeshi; Akatsu, Tomohiro; Akutsu, Hiroyoshi*

no journal, , 

no abstracts in English

Oral presentation

Development of laser-irradiation tool using the composite-type optical fiberscope for formulas hemostasis / coagulation in a neuroendoscopic surgery

Watanabe, Shinya*; Akutsu, Hiroyoshi*; Yamamoto, Tetsuya*; Ihara, Satoshi*; Oka, Kiyoshi; Seki, Takeshi; Akatsu, Tomohiro; Matsumura, Akira*

no journal, , 

no abstracts in English

Oral presentation

Medical application of a composite-type optical fiberscope

Oka, Kiyoshi; Seki, Takeshi*; Akatsu, Tomohiro*; Usuda, Jitsuo*; Kobayashi, Hiroshi*; Akutsu, Hiroyoshi*; Kikuta, Kenichiro*

no journal, , 

no abstracts in English

Oral presentation

Development of a laser irradiating device for hemostasis in neuroendoscopic surgery; Verification of hemostatic effect in vivo

Seki, Takeshi*; Akatsu, Tomohiro*; Oka, Kiyoshi; Watanabe, Shinya*; Akutsu, Hiroyoshi*

no journal, , 

no abstracts in English

Oral presentation

Development of a novel hemostatic and coagulating device in neuroendoscopic surgery; Usefulness of laser irradiating composite type optical fiberscope

Watanabe, Shinya*; Akutsu, Hiroyoshi*; Oka, Kiyoshi; Seki, Takeshi*; Akatsu, Tomohiro*; Tanaka, Hidemine*; Yamamoto, Tetsuya*; Ihara, Satoshi*; Matsumura, Akira*

no journal, , 

no abstracts in English

15 (Records 1-15 displayed on this page)
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