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Gade, A.*; Basin, D.*; Brown, B. A.*; Campbell, C. M.*; Cook, J. M.*; Ettenauer, S.*; Glasmacher, T.*; Kemper, K. W.*; McDaniel, S.*; Obertelli, A.*; et al.
Physical Review C, 83(4), p.044305_1 - 044305_5, 2011/04
Times Cited Count:21 Percentile:75.6(Physics, Nuclear)no abstracts in English
Fallon, P.*; Rodriguez-Vieitez, E.*; Macchiavelli, A. O.*; Gade, A.*; Tostevin, J. A.*; Adrich, P.*; Bazin, D.*; Bowen, M.*; Campbell, C. M.*; Clark, R. M.*; et al.
Physical Review C, 81(4), p.041302_1 - 041302_5, 2010/04
Times Cited Count:40 Percentile:88.69(Physics, Nuclear)no abstracts in English
Hidaka, Koshi*; Kimura, Toru*; Abdel-Rahman, H. M.*; Nguyen, J.-T.*; McDaniel, K. F.*; Kohlbrenner, W. E.*; Molla, A.*; Adachi, Motoyasu; Tamada, Taro; Kuroki, Ryota; et al.
Journal of Medicinal Chemistry, 52(23), p.7604 - 7617, 2009/07
Times Cited Count:19 Percentile:44.7(Chemistry, Medicinal)A series of HIV protease inhibitor based on the allophenylnorstatine structure with various P2' moieties were synthesized. Among these analogues, we discovered that a small allyl group would maintain potent enzyme inhibitory activity compared to that of the -methylbenzyl moiety in clinical candidate 1 (KNI-764, also known as JE-2147, AG-1776 or SM-319777). Introduction of an anilinic amino group to 2 (KNI-727) improved water-solubility and anti-HIV-1 activity. X-ray crystallographic analysis of 13k (KNI-1689) with a -methallyl group at P2' position revealed hydrophobic interactions with Ala28, Ile84, and Ile50' similar to that of 1. The presence of an additional methyl group on the allyl group in compound 13k significantly increased anti-HIV activity over 1, while providing a rational drug design for structural minimization and improving membrane permeability.
Roach, C. M.*; Walters, M.*; Budny, R. V.*; Imbeaux, F.*; Fredian, T. W.*; Greenwald, M.*; Stillerman, J. A.*; Alexander, D. A.*; Carlsson, J.*; Cary, J. R.*; et al.
Nuclear Fusion, 48(12), p.125001_1 - 125001_19, 2008/12
Times Cited Count:35 Percentile:28.57(Physics, Fluids & Plasmas)This paper documents the public release PR08 of the International Tokamak Physics Activity profile database, which should be of particular interest to the magnetic confinement fusion community. Data from a wide variety of interesting discharges from many of the world's leading tokamak experiments are now made available in PR08, which also includes predictive simulations of an initial set of operating scenarios for ITER. In this paper we describe the discharges that have been included and the tools that are available to the reader who is interested in accessing and working with the data.
Gade, A.*; Adrich, P.*; Bazin, D.*; Bowen, M. D.*; Brown, B. A.*; Campbell, C. M.*; Cook, J. M.*; Ettenauer, S.*; Glasmacher, T.*; Kemper, K. W.*; et al.
Physical Review Letters, 99(7), p.072502_1 - 072502_4, 2007/08
Times Cited Count:76 Percentile:90.4(Physics, Multidisciplinary)no abstracts in English
Fujita, Takaaki; Aniel, T.*; Barbato, E.*; Behn, R.*; Bell, R. E.*; Field, A. R.*; Fukuda, Takeshi*; Gohil, P.*; Ida, Katsumi*; Imbeaux, F.*; et al.
Europhysics Conference Abstracts, 27A, 4 Pages, 2003/00
no abstracts in English
Stoica, A. D.*; Yang, L.*; Wang, X.-L.*; Stoica, M.*; An, K.*; Skorpenske, H.*; Conaster, R.*; Rey, C.*; Reiersen, W.*; Daniel, H.*; et al.
no journal, ,
no abstracts in English
Micheau, C.; Ueda, Yuki; Motokawa, Ryuhei; Moussaoui, S.*; Makombe, E.*; Daniel, M.*; Berthon, L.*; Bourgeois, D.*; Akutsu, Kazuhiro*
no journal, ,