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Journal Articles

Radiation biology of ${it Caenorhabditis elegans}$; Germ cell response, aging and behavior

Sakashita, Tetsuya; Takanami, Takako*; Yanase, Sumino*; Hamada, Nobuyuki*; Suzuki, Michiyo; Kimura, Takafumi*; Kobayashi, Yasuhiko; Ishii, Naoaki*; Higashitani, Atsushi*

Journal of Radiation Research, 51(2), p.107 - 121, 2010/03

https://doi.org/10.1269/jrr.09100
 Times Cited Count：35 Percentile：64.56(Biology)

The study of radiation effect in ${it Caenorhabditis (C.) elegans}$ have been carried out over three decades and now allow for understanding at the molecular, cellular and individual levels. This review describes the current knowledge of the biological effects of ionizing irradiation with a scope of the germ line, aging and behavior. ${it C. elegans}$ may be a good ${it in vivo}$ model system in the field of radiation biology.

Journal Articles

Production of no-carrier-added $$^{64}$$Cu and applications to molecular imaging by PET and PETIS as a biomedical tracer

Watanabe, Shigeki; Iida, Yasuhiko*; Suzui, Nobuo; Katabuchi, Tatsuya*; Ishii, Satomi; Kawachi, Naoki; Hanaoka, Hirofumi*; Watanabe, Satoshi; Matsuhashi, Shimpei; Endo, Keigo*; et al.

Journal of Radioanalytical and Nuclear Chemistry, 280(1), p.199 - 205, 2009/04

https://doi.org/10.1007/s10967-008-7443-9
 Times Cited Count：24 Percentile：82.24(Chemistry, Analytical)

Journal Articles

Locomotion-learning behavior relationship in ${it Caenorhabditis elegans}$ following $$gamma$$-ray irradiation

Sakashita, Tetsuya; Hamada, Nobuyuki*; Ikeda, Daisuke*; Suzuki, Michiyo; Yanase, Sumino*; Ishii, Naoaki*; Kobayashi, Yasuhiko

Journal of Radiation Research, 49(3), p.285 - 291, 2008/05

https://doi.org/10.1269/jrr.07102
 Times Cited Count：12 Percentile：39.68(Biology)

We investigated the effects of ionizing radiation (IR) exposure on the relationship between locomotion and salt chemotaxis learning behavior of ${it C. elegans}$. We found that effects of pre-learning irradiation on locomotion were significantly correlated with the salt chemotaxis learning performance, whereas locomotion was not directly related to chemotaxis to NaCl. On the other hand, locomotion was positively correlated with salt chemotaxis of animals which were irradiated during learning, and the correlation disappeared with increasing doses. These results suggest an indirect relationship between locomotion and salt chemotaxis learning in ${it C. elegans}$, and that IR inhibits the innate relationship between locomotion and chemotaxis, which is related to salt chemotaxis learning conditioning of ${it C. elegans}$.

Journal Articles

Modulatory effect of ionizing radiation on food-NaCl associative learning; The Role of $$gamma$$ subunit of G protein in ${it Caenorhabditis elegans}$

Sakashita, Tetsuya; Hamada, Nobuyuki*; Ikeda, Daisuke*; Yanase, Sumino*; Suzuki, Michiyo; Ishii, Naoaki*; Kobayashi, Yasuhiko

FASEB Journal, 22(3), p.713 - 720, 2008/03

https://doi.org/10.1096/fj.07-9259com
 Times Cited Count：11 Percentile：37.36(Biochemistry & Molecular Biology)

We analyzed the effects of ionizing radiation (IR) on a food-NaCl associative learning paradigm of adult ${it Caenorhabditis elegans}$, and observed that a decrease in chemotaxis toward NaCl occurs only after combined starvation and exposure to NaCl. Exposure to IR induced an additional decrease in chemotaxis immediately after an acute dose in the transition stage of the food-NaCl associative learning. Strikingly, chronic irradiation induced negative chemotaxis in the exposed animals, i.e., the primary avoidance response. IR-induced additional decreases in chemotaxis following acute and chronic irradiations were significantly suppressed in the ${it gpc-1}$ mutant, which was defective in GPC-1. Chemotaxis to cAMP, but not to lysine and benzaldehyde, was influenced by IR during the food-NaCl associative learning. Our novel findings suggest that IR behaves as a modulator in the food-NaCl associative learning via ${it C. elegans}$ GPC-1 and a specific neuronal network.

Journal Articles

Effects of $$gamma$$-ray irradiation on olfactory adaptation to benzaldehyde in ${it Caenorhabditis elegans}$

Sakashita, Tetsuya; Hamada, Nobuyuki*; Suzuki, Michiyo; Ikeda, Daisuke*; Yanase, Sumino*; Ishii, Naoaki*; Kobayashi, Yasuhiko

Uchu Seibutsu Kagaku, 21(4), p.117 - 120, 2007/12

https://doi.org/10.2187/bss.21.117

Using ${it Caenorhabditis elegans}$ as a model organism for studying the nervous system, we investigated the effects of $$gamma$$-ray irradiation on olfactory adaptation to benzaldehyde, in which animals show a decrease in chemotaxis to benzaldehyde. Irradiation during the conditioning for adaptation to benzaldehyde did not induce an additional decrease in chemotaxis immediately after irradiation. On the other hand, at 1 h after irradiation, the progress of adaptation to benzaldehyde was interrupted by irradiation with the highest dose. These results indicate that impaired olfactory adaptation to benzaldehyde following irradiation is different from salt chemotaxis learning in ${it C. elegans}$. Our findings suggest that the profile of radiation-induced response depends on the function of the nervous system in ${it C. elegans}$.

Journal Articles

Extended steady-state and high-beta regimes of net-current free heliotron plasmas in the Large Helical Device

Motojima, Osamu*; Yamada, Hiroshi*; Komori, Akio*; Oyabu, Nobuyoshi*; Muto, Takashi*; Kaneko, Osamu*; Kawahata, Kazuo*; Mito, Toshiyuki*; Ida, Katsumi*; Imagawa, Shinsaku*; et al.

Nuclear Fusion, 47(10), p.S668 - S676, 2007/10

https://doi.org/10.1088/0029-5515/47/10/S15
 Times Cited Count：34 Percentile：73.64(Physics, Fluids & Plasmas)

The performance of net-current free heliotron plasmas has been developed by findings of innovative operational scenarios in conjunction with an upgrade of the heating power and the pumping/fuelling capability in the Large Helical Device (LHD). Consequently, the operational regime has been extended, in particular, with regard to high density, long pulse length and high beta. Diversified studies in LHD have elucidated the advantages of net-current free heliotron plasmas. In particular, an internal diffusion barrier (IDB) by a combination of efficient pumping of the local island divertor function and core fuelling by pellet injection has realized a super dense core as high as 5$$times$$10$$^{20}$$ m$$^{-3}$$, which stimulates an attractive super dense core reactor. Achievements of a volume averaged beta of 4.5% and a discharge duration of 54 min with a total input energy of 1.6 GJ (490 kW on average) are also highlighted. The progress of LHD experiments in these two years is overviewed by highlighting IDB, high-beta and long pulse.

Journal Articles

Extended steady-state and high-beta regimes of net-current free heliotron plasmas in the large helical device

Motojima, Osamu*; Yamada, Hiroshi*; Komori, Akio*; Oyabu, Nobuyoshi*; Kaneko, Osamu*; Kawahata, Kazuo*; Mito, Toshiyuki*; Muto, Takashi*; Ida, Katsumi*; Imagawa, Shinsaku*; et al.

Proceedings of 21st IAEA Fusion Energy Conference (FEC 2006) (CD-ROM), 12 Pages, 2007/03

http://www-naweb.iaea.org/napc/physics/FEC/FEC2006/html/node31.htm#5947

The performance of net-current free Heliotron plasmas has been developed by findings of innovative operational scenarios in conjunction with an upgrade of the heating power and the pumping/fueling capability in the Large Helical Device (LHD). Consequently, the operational regime has been extended, in particular, with regard to high density, long pulse length and high beta. Diversified studies in LHD have elucidated the advantages of net-current free heliotron plasmas. In particular, an Internal Diffusion Barrier (IDB) by combination of efficient pumping of the local island divertor function and core fueling by pellet injection has realized a super dense core as high as 5$$times$$10$$^{20}$$m$$^{-3}$$, which stimulates an attractive super dense core reactor. Achievements of a volume averaged beta of 4.5 % and a discharge duration of 54-min. with a total input energy of 1.6 GJ (490 kW in average) are also highlighted. The progress of LHD experiments in these two years is overviewed with highlighting IDB, high $$beta$$ and long pulse.

JAEA Reports

None

Todokoro, Akio; Watahiki, Masatoshi; Kihara, Yoshiyuki; Ishii, Yasuhiko*; Ogasawara, Masahiro*; Otaka, Akihiro*

PNC TN8410 96-238, 86 Pages, 1996/08

PNC-TN8410-96-238.pdf:2.3MB

None

Oral presentation

Micro-ion-beam applications to life science

Fukuda, Mitsuhiro; Arakawa, Kazuo; Sato, Takahiro; Okumura, Susumu; Saito, Yuichi; Kashiwagi, Hirotsugu; Miyawaki, Nobumasa; Yuri, Yosuke; Ishii, Yasuyuki; Kobayashi, Yasuhiko; et al.

no journal, , 

no abstracts in English

Oral presentation

Multi-tracer imaging using CdTe $$gamma$$-camera for studying molecular imaging for plant science

Kawachi, Naoki; Fujimaki, Shu; Suzui, Nobuo; Ishii, Satomi; Ishioka, Noriko; Matsuhashi, Shimpei; Sato, Takahiro; Watanabe, Shin*; Takeda, Shinichiro*; Takahashi, Tadayuki*; et al.

no journal, , 

Oral presentation

Multi-tracer imaging using CdTe $$gamma$$-camera for studying dynamics of nutrients and pollutants in intact plants

Kawachi, Naoki; Fujimaki, Shu; Suzui, Nobuo; Ishii, Satomi; Ishioka, Noriko; Matsuhashi, Shimpei; Sato, Takahiro; Watanabe, Shin*; Takeda, Shinichiro*; Takahashi, Tadayuki*; et al.

no journal, , 

no abstracts in English

Oral presentation

Modulatory effect of ionizing radiation on food-NaCl associative learning; The Role of $$gamma$$ subunit of G protein in ${it Caenorhabditis elegans}$

Sakashita, Tetsuya; Hamada, Nobuyuki*; Ikeda, Daisuke*; Yanase, Sumino*; Suzuki, Michiyo; Ishii, Naoaki*; Kobayashi, Yasuhiko

no journal, , 

Exposure to IR induced an additional decrease in chemotaxis immediately after an acute dose in the transition stage of the salt chemotaxis learning. Chronic irradiation induced negative chemotaxis in the exposed animals, i.e., the primary avoidance response. IR-induced additional decreases in chemotaxis following acute and chronic irradiations were significantly suppressed in the ${it gpc-1}$ mutant, which was defective in GPC-1 (one of the two $$gamma$$ subunits of the heterotrimeric G-protein). Chemotaxis to cAMP, but not to lysine and benzaldehyde, was influenced by IR during the food-NaCl associative learning. Our novel findings suggest that IR behaves as a modulator in the salt chemotaxis learning via ${it C. elegans}$ GPC-1 and a specific neuronal network, and may shed light on the modulatory effect of IR on learning.

Oral presentation

Effects of $$gamma$$-ray irradiation on olfactory adaptation to benzaldehyde in ${it Caenorhabditis elegans}$

Sakashita, Tetsuya; Suzuki, Michiyo; Hamada, Nobuyuki*; Ikeda, Daisuke*; Yanase, Sumino*; Ishii, Naoaki*; Kobayashi, Yasuhiko

no journal, , 

Using ${it Caenorhabditis elegans}$ as a model organism for studying the nervous system, we investigated the effects of $$gamma$$-ray irradiation on olfactory adaptation to benzaldehyde, in which animals show a decrease in chemotaxis to benzaldehyde. Irradiation during the conditioning for adaptation to benzaldehyde did not induce an additional decrease in chemotaxis immediately after irradiation. On the other hand, at 1 h after irradiation, the progress of adaptation to benzaldehyde was interrupted by $$gamma$$-irradiation with the highest dose. These results indicate that impaired olfactory adaptation to benzaldehyde following $$gamma$$-irradiation is different from salt chemotaxis learning in ${it C. elegans}$. Our findings suggest that the profile of radiation-induced response depends on the function of the nervous system in ${it C. elegans}$.

Oral presentation

Approach to the radiobiological study of ${it Caenorhabditis elegans}$ using heavy-ion microbeam

Sakashita, Tetsuya; Suzuki, Michiyo; Hamada, Nobuyuki*; Ikeda, Daisuke*; Fukamoto, Kana; Yokota, Yuichiro; Funayama, Tomoo; Yanase, Sumino*; Higashitani, Atsushi*; Ishii, Naoaki*; et al.

no journal, , 

Using ${it Caenorhabditis elegans}$ as a model multicellular organism, we push forward a heavy-ion microbeam irradiation individual-study. As for about 1.2 mm in a range of carbon ions in water, all cells and tissues of ${it C. elegans}$ are microbeam irradiation objects. Sugimoto et al. showed DNA-damage-induced cell cycle arrest and apoptosis in locally irradiated areas of ${it C. elegans}$. We focus the nervous system of ${it C. elegans}$ and study the effects of localized irradiation on salt chemotaxis learning behavior. However, the anesthetic method for fixation of animals is not usable because the whole body irradiation of $$^{60}$$Co $$gamma$$ rays affected only transition stage of the conditioning for salt chemotaxis learning. Thus, now we are constructing the heavy-ion microbeam irradiation system for living target ${it C. elegans}$.

Oral presentation

Learning behavior of ${it C. elegans}$ and radiation effects

Sakashita, Tetsuya; Suzuki, Michiyo; Hamada, Nobuyuki*; Ikeda, Daisuke*; Yanase, Sumino*; Ishii, Naoaki*; Kobayashi, Yasuhiko

no journal, , 

We studied the effects of $$gamma$$-irradiation on the salt chemotaxis learning of ${it C. elegans}$, that is well known as a model organism for the nervous system. As a result, we found that chemotaxis to NaCl immediately after irradiation was significantly decreased only during the salt chemotaxis learning. In addition, the radiation-induced resoponse is significantly suppressed in the ${it gpc-1}$ mutant. These results suggested that the effects of ionizing radiation on the salt chemotaxis learning behavior of ${it C. elegans}$ mediated through GPC-1 localized in the specific sensory neurons.

Oral presentation

Modulatory effect of ionizing radiation on salt chemotaxis learning; The Role of G protein $$gamma$$ subunit in ${it Caenorhabditis elegans}$

Hamada, Nobuyuki*; Sakashita, Tetsuya; Ikeda, Daisuke*; Yanase, Sumino*; Suzuki, Michiyo; Ishii, Naoaki*; Kobayashi, Yasuhiko

no journal, , 

Well-fed adult animals were exposed to cobalt-60 $$gamma$$-rays, followed by the chemotaxis assay. A decrease in chemotaxis toward NaCl occurred only after combined starvation and exposure to NaCl. Irradiation led to an additional decrease in chemotaxis immediately after an acute dose in the transition stage of salt chemotaxis learning. Strikingly, chronic irradiation induced negative chemotaxis in the exposed animals, i.e., the primary avoidance response. Radiation-induced additional decreases in chemotaxis following acute and chronic irradiations were significantly suppressed in the ${it gpc-1}$ mutant, which was defective in GPC-1 (one of the two $$gamma$$ subunits of the heterotrimeric G protein). The data suggest that radiation behaves as a modulator in salt chemotaxis learning via ${it C. elegans}$ GPC-1 and a specific neuronal network, and may shed light on the modulatory effect of radiation on learning.

Oral presentation

Efficacy of in-air microanalysis of particles in interstitial pneumonia lung tissue

Koga, Yasuhiko*; Kaira, Kyoichi*; Yamada, Masanobu*; Dobashi, Kunio*; Matsuzaki, Shinichi*; Hisada, Takeshi*; Koka, Masashi; Yamada, Naoto; Sato, Takahiro; Yokoyama, Akihito; et al.

no journal, , 

17 (Records 1-17 displayed on this page)
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