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Tsuchida, Hidetsugu*; Majima, Takuya*; Kai, Takeshi
Oyo Butsuri, 91(9), p.553 - 557, 2022/09
In recent years, basic research has been conducted to understand the biological effects of radiation at the atomic level toward advancing particle beam cancer treatment. Here we show some recent results on the basic process of biomolecular damage caused by ion beams in liquid water. A biomolecular solution target was introduced to the vacuum by a liquid molecular beam or microdroplet method. Secondary ion mass spectrometry was applied to measure the fragments of biomolecules emitted from a target irradiated with an ion beam. For the simulation study using a PHITS code, physical nature of secondary electrons produced by ion beam in water was analyzed. The experimental and simulation research determined the energy range of secondary electrons involved in damaging biomolecules in liquid water caused by ion beams. The damage process by secondary electrons near the ion track is described.
Tsuchida, Hidetsugu*; Kai, Takeshi; Kitajima, Kensei*; Matsuya, Yusuke; Majima, Takuya*; Saito, Manabu*
European Physical Journal D, 74(10), p.212_1 - 212_7, 2020/10
Times Cited Count：3 Percentile：17.64(Optics)Fundamental study of interaction between biomolecules and heavy ions in water is very important to predict an initial stage of radiation biological effects. A heavy ion irradiation experiment into droplet target assumed as a biological system in a vacuum was performed to measure production yields of cations and anions for glycine, which was ejected from the droplet target to the vacuum. However, the production mechanisms have been unknown. The PHITS code adapting ion track structure mode was used to analyze the production mechanisms from the dose evaluation at the surface between the vacuum and the water. It is found that induction yields of ionization and excitation, and dissociative electron attachment involved in the secondary electrons were correlated with the production yields of cations and anions of the glycine. The results provide us newly scientific insights to predict an initial stage of radiation biological effects.
Nakajima, Kyo*; Teramoto, Takahiro*; Akagi, Hiroshi; Fujikawa, Takashi*; Majima, Takuya*; Minemoto, Shinichiro*; Ogawa, Kanade*; Sakai, Hirofumi*; Togashi, Tadashi*; Tono, Kensuke*; et al.
Scientific Reports (Internet), 5, p.14065_1 - 14065_11, 2015/09
Times Cited Count：38 Percentile：84.13(Multidisciplinary Sciences)We report on the measurement of deep inner-shell 2p X-ray photoelectron diffraction (XPD) patterns from laser-aligned I
molecules using X-ray free-electron laser (XFEL) pulses. The XPD patterns of the I molecules, aligned parallel to the polarization vector of the XFEL, were well matched with our theoretical calculations. Further, we propose a criterion for applying our molecular-structure-determination methodology to the experimental XPD data. In turn, we have demonstrated that this approach is a significant step toward the time-resolved imaging of molecular structures.
ions through micro- and nano-capillariesTsuchida, Hidetsugu*; Majima, Takuya*; Tomita, Shigeo*; Sasa, Kimikazu*; Narumi, Kazumasa; Saito, Yuichi; Chiba, Atsuya; Yamada, Keisuke; Hirata, Koichi*; Shibata, Hiromi*; et al.
Nuclear Instruments and Methods in Physics Research B, 315, p.336 - 340, 2013/11
Times Cited Count：3 Percentile：26.71(Instruments & Instrumentation) microbeams by single-microcapillary methodsTsuchida, Hidetsugu*; Majima, Takuya*; Tomita, Shigeo*; Sasa, Kimikazu*; Narumi, Kazumasa; Saito, Yuichi; Chiba, Atsuya; Yamada, Keisuke; Hirata, Koichi*; Shibata, Hiromi*; et al.
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Tsuchida, Hidetsugu*; Nakajima, Kaoru*; Yokoe, Junya*; Sugiyama, Motohiko*; Ota, Yushi*; Majima, Takuya*; Shibata, Hiromi*; Tomita, Shigeo*; Sasa, Kimikazu*; Hirata, Koichi*; et al.
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no abstracts in English
Tsuchida, Hidetsugu*; Majima, Takuya*; Tomita, Shigeo*; Sasa, Kimikazu*; Hirata, Koichi*; Shibata, Hiromi*; Saito, Yuichi; Narumi, Kazumasa; Chiba, Atsuya; Yamada, Keisuke; et al.
no journal, ,
no abstracts in English
Konishi, Suzuka*; Minagawa, Hideaki*; Majima, Takuya*; Imai, Makoto*; Saito, Manabu*; Hirade, Tetsuya; Tsuchida, Hidetsugu*
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To clarify the damage behavior under ion irradiation in quartz glass, Age-Momentum Correlation measurement that is a coincidence measurement of positron annihilation lifetime and annihilation gamma ray Doppler broadening was performed under 2 MeV proton irradiation. From the change in momentum distribution of electrons involved in positron annihilation in voids of the quartz glass, flux dependence of damage behavior could be detected.
