Features of accelerator-based neutron source for boron neutron capture therapy calculated by Particle and Heavy Ion Transport code System (PHITS)

Matsuya, Yusuke; Kusumoto, Tamon*; Yachi, Yoshie*; Hirata, Yuho; Miwa, Misako*; Ishikawa, Masayori*; Date, Hiroyuki*; Iwamoto, Yosuke; Matsuyama, Shigeo*; Fukunaga, Hisanori*

AIP Advances (Internet), 12(2), p.025013_1 - 025013_9, 2022/02

https://doi.org/10.1063/5.0077782

Boron Neutron Capture Therapy (BNCT) is a radiation therapy, which can selectively eradicate solid tumors by -particles and Li ions generated through the nuclear reaction between thermal neutron and B in tumor cells. With the development of accelerator-based neutron sources that can be installed in medical institutions, accelerator-based boron neutron capture therapy is expected to become available at several medical institutes around the world in the near future. Lithium is one of the targets that can produce thermal neutrons from the Li(p,n)Be near-threshold reaction. Particle and Heavy Ion Transport code System (PHITS) is a general-purpose Monte Carlo code, which can simulate a variety of diverse particle types and nuclear reactions. The latest PHITS code enables simulating the generation of neutrons from the Li(p,n)Be reactions by using Japanese Evaluated Nuclear Data Library (JENDL-4.0/HE). In this study, we evaluated the neutron fluence using the PHITS code by comparing it to reference data. The subsequent neutron transport simulations were also performed to evaluate the boron trifluoride (BF) detector responses and the recoiled proton fluence detected by a CR-39 plastic detector. As a result, these comparative studies confirmed that the PHITS code can accurately simulate neutrons generated from an accelerator using a Li target. The PHITS code has a significant potential for contributing to more precise evaluating accelerator-based neutron fields and understandings of therapeutic effects of BNCT.

Increased antitumor effect of chemotherapy, using radiosensitive microcapsules containing anti-RLIP076

Harada, Satoshi*; Ehara, Shigeru*; Ishii, Keizo*; Sato, Takahiro; Yamazaki, Hiromichi*; Matsuyama, Shigeo*; Kamiya, Tomihiro

JAEA-Review 2011-043, JAEA Takasaki Annual Report 2010, P. 89, 2012/01

https://doi.org/10.11484/jaea-review-2011-043

The Kinetics of Fe and Ca for the development of radiation-induced apoptosis by micro-PIXE imaging

Harada, Satoshi*; Tamakawa, Yoshiharu*; Ishii, Keizo*; Tanaka, Akira*; Sato, Takahiro; Matsuyama, Shigeo*; Yamazaki, Hiromichi*; Kamiya, Tomihiro; Sakai, Takuro; Arakawa, Kazuo; et al.

Nuclear Instruments and Methods in Physics Research B, 189(1-4), p.437 - 442, 2002/04

https://doi.org/10.1016/S0168-583X(01)01121-1

To study the interactions between the induction of radiation-induced apoptosis and trace elements kinetics, human leukemia cells were irradiated in vitro by Co rays, after which the cells were evaluated for the detection of apoptosis and trace element imaging was carried out. The frequency of apoptosis was obtained by microscopic assay using TUNEL staining. The trace element distribution in the cell was determined by micro-PIXE. In the early phase of apoptosis, the maximum level of Fe accumulation was observed in the cell stroma. In the mid to end phase, Fe accumulation was diminished, and instead, Ca accumulation increased and Zn decreased in the nucleus. There appear to be two steps for the development of apoptosis: (1) the signaling from cell stroma to nucleus by Fe or an Fe-containing enzyme; and (2) the degeneration of the nucleus by Ca-dependent enzyme, and release of Zn from digested nucleus. Those strong accumulations may be new markers for apoptosis.

Measurement and theoretical analysis of neutron elastic scattering and inelastic reactions leading to a three-body final state for Li at 10 to 20 MeV

Chiba, Satoshi; *; *; *; Matsuyama, Shigeo*; Shibata, Keiichi; Iwamoto, Osamu; A.J.Koning*; G.M.Hale*; M.B.Chadwick*; et al.

Physical Review C, 58(4), p.2205 - 2216, 1998/10

https://doi.org/10.1103/PhysRevC.58.2205

no abstracts in English

Development of a fast multi-parameter data acquisition system for microbeam analyses

Sakai, Takuro; *; Hirao, Toshio; Kamiya, Tomihiro; *; *; Matsuyama, Shigeo*; *; Ishii, Keizo*

Nuclear Instruments and Methods in Physics Research B, 136-138, p.390 - 394, 1998/00

https://doi.org/10.1016/S0168-583X(97)00862-8

no abstracts in English

Change of elemental distribution in sections of brain found by in-air micro-PIXE

Sakurai, Eiko*; Ishii, Keizo*; Yamanaka, Kentaro*; Okura, Satoru*; Fujiki, Kota*; Yamazaki, Hiromichi*; Matsuyama, Shigeo*; Kamiya, Tomihiro; Sato, Takahiro; Arakawa, Kazuo*; et al.

no journal, , 

Cognitive degradation and behavior disorder occur under the mental disease caused by stimulant drugs. In this study, it was continuously administered to mice. After that, neuropoiesis of dentate gyrus and trace elements in its brain were analyzed by in-air micro-PIXE. As a result, the distribution of trace elements was different from that of normal mice.

Technique for measuring distribution of trace elements using micro-PIXE

Sato, Takahiro; Koka, Masashi; Kada, Wataru; Yokoyama, Akihito; Okubo, Takeru; Yamazaki, Akiyoshi; Ishii, Yasuyuki; Kamiya, Tomihiro; Matsuyama, Shigeo*; Ishii, Keizo*

no journal, , 

In order to make elemental analysis in a minute cell, we developed in-air micro-PIXE analysis system in which light-ion microbeam of diameter 0.25m is used, and the imaging of the trace-element distribution was successfully carried out. This system is widely applied in the fields of medicine, biology, pharmacy, and dentistry.

Miniaturization of microcapsule and its dynamics in a mouse

Harada, Satoshi*; Ehara, Shigeru*; Ishii, Keizo*; Yamazaki, Hiromichi*; Matsuyama, Shigeo*; Sato, Takahiro; Koka, Masashi; Kamiya, Tomihiro

no journal, , 

no abstracts in English

Character of elemental distribution in lung endothelial cell of alveolocapillary barrier; Influence of mouse strains and nicotine

Sakurai, Eiko*; Sakurai, Eiichi*; Ishii, Keizo*; Koshio, Shigeki*; Ito, Shun*; Matsuyama, Shigeo*; Koka, Masashi; Yamada, Naoto; Kitamura, Akane; Sato, Takahiro; et al.

no journal, , 

no abstracts in English

Basic research programs of vitrification technology for waste volume reduction, 95; Investigation of the decomposition and reuse of the spent adsorbent for extraction chromatography technology

Miyazaki, Yasunori; Sano, Yuichi; Takeuchi, Masayuki; Arai, Tsuyoshi*; Kim, S.-Y.*; Wu, H.*; Miwa, Misako*; Matsuyama, Shigeo*

no journal, , 

Separation of minor actinides (MA; Am, Cm) is social demand to reduce the volume and toxicity of radioactive waste generated by spent nuclear fuel reprocessing. We have proposed extraction chromatography that employs the TEHDGA-impregnated adsorbent in a separation column. From the previous study, MA recovery from the real radioactive waste liquid was achieved, and a flowsheet study is continued to improve the product purity (or decontamination coefficient). On the other hand, we are also investigating the decomposition and reuse of spent adsorbent. In this presentation, both of the degradability of the adsorbent by the Fenton reaction and the reusability of the re-impregnated adsorbent from the batch-wise adsorption test results are reported by the element distribution by micro-PIXE analysis.