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Sekine, Yurina; Endo, Hitoshi*; Iwase, Hiroki*; Takeda, Shigeo*; Mukai, Sadaatsu*; Fukazawa, Hiroshi; Littrell, K. C.*; Sasaki, Yoshihiro*; Akiyoshi, Kazunari*
Journal of Physical Chemistry B, 120(46), p.11996 - 12002, 2016/11
Times Cited Count：11 Percentile：29.31(Chemistry, Physical)The detailed structure of a nanogel formed by self-association of cholesterol-bearing pullulans (CHP) was determined by contrast variation small-angle neutron scattering. The decomposition of scattering intensities into partial scattering functions of each CHP nanogel component, i.e., pullulan, cholesterol, and the cross-term between the pullulan and the cholesterol allows us to investigate the internal structure of the nanogel. The effective spherical radius of the skeleton formed by pullulan chains was found to be about 8.1 nm. In the CHP nanogel, there are about 19 cross-linking points where a cross-linking point is formed by aggregation of trimer cholesterol molecules with the spatially inhomogeneous distribution of the mass fractal dimension of 2.6. The average radius of the partial chains can also be determined to be 1.7 nm. As the result, the complex structure of the nanogels is coherently revealed at the nanoscopical level.
Rn and its decay products coupled with a mesoscale meteorological model, 1; Model description and validationNishizawa, Masato; Nagai, Haruyasu; Chino, Masamichi; Moriizumi, Jun*; Yoshioka, Katsuhiro*; Okura, Takehisa; Yamazawa, Hiromi*; Iida, Takao*; Mukai, Hitoshi*; Tojima, Yasunori*; et al.
Journal of Nuclear Science and Technology, 44(11), p.1458 - 1466, 2007/11
Times Cited Count：5 Percentile：37.16(Nuclear Science & Technology)A three-dimensional Eulerian numerical model for Rn and its decay products coupled with a mesoscale meteorological model has been developed and applied to the reproduction of the daily and monthly variations of Rn concentration, the monthly variation of 
Pb deposition in Japan and the temporal variation of 
dose rate after the cold front passage in the coastal area of the Japan Sea for the verification of model capability. The results are as follows: (1) The model reproduced the monthly variation of surface Rn concentration in remote islands, but underestimated inland concentration due to coarse vertical resolution near the surface of the model. (2) The model reproduced the seasonal variation of the observed and the long-term yearly averaged Pb depositions as long as precipitations are predicted precisely. (3) The model reproduced the rise of dose rate in precipitation accompanied with the cold front passage. In particular, Rn decay products in melted snow and graupel contributed the rise of dose rate.
Fuchimukai, Junichi*; Yamaguchi, Hitoshi*; Meguro, Yoshihiro; Kubota, Toshio*; Igarashi, Shukuro*
Solvent Extraction Research and Development, Japan, 13, p.139 - 146, 2006/00
no abstracts in English
Mukai, Naoki*; Watanabe, Hirohisa*; Shimamoto, Masaki*; Ishida, Hitoshi*; Nakajima, Hideo; Chida, Yutaka; Iguchi, Masahide
no journal, ,
Toroidal Field (TF) Coil as main components of International Thermonuclear Experimental Reactor (ITER) is huge welding structure using high tensile and high toughness stainless steel. In the current fabrication plan, maximum weld depth is 260 mm and weld joints are also required high strength and toughness, and at the same time high productivity is required. Therefore narrow gap automatic TIG welding with full austenitic filler wire is planed to apply. During the trial fabrication, micro cracks were observed in the weld metal for heavy thick weld joints. It was found in order to minimize such micro cracks increasing of ductility at high temperature was efficient by the investigation of mechanism of initiation of cracks. Practically, by adding the REM (Rear Earth Metal) in the melting process sulfer contents could be decreased to 10 ppm (50 ppm for usual wire) and micro cracks could be reduced. Kobe Stee, LTD has executed this investigation and JAEA has made an advice.
Sekine, Yurina; Endo, Hitoshi*; Iwase, Hiroki*; Fukazawa, Hiroshi; Mukai, Sadaatsu*; Akiyoshi, Kazunari*
no journal, ,
Cholesterol-bearing pullulan (CHP) spontaneously forms stable nanogel of ca. 30 nm in size in water. Because the CHP nanogels can trap various proteins spontaneously and release them in their native form to environment, they are valuable for use in protein delivery systems, particularly for cancer vaccines, and so on. The distribution and position of cross-linking domain are important factor determining the properties of nanogels. The aim of this study is to investigate the distribution and position of cross-linking domain of nanogels by means of contrast variation small-angle neutron scattering (CV-SANS). We had the CV-SANS measurement of the CHP nanogel dispersed in complex solvent of D
O/HO to clarify the microscopic structure of cross-linking domain of CHP nanogels. In this presentation, we will discuss the detailed structure of the CHP nanogel analyzed from the result of CV-SANS.
Sekine, Yurina; Fukazawa, Hiroshi; Endo, Hitoshi*; Iwase, Hiroki*; Mukai, Sadaatsu*; Littrell, K. C.*; Fernandez-Baca, J. A.*; Akiyoshi, Kazunari*
no journal, ,
Cholesterol-bearing pullulan (CHP) spontaneously forms stable nanogel of ca. 30 nm in size in water. Because the CHP nanogels can trap various proteins spontaneously and release them in their native form to environment, they are valuable for use in protein delivery systems. The aim of this study is to investigate the distribution and position of cross-linking domain of nanogels by means of contrast variation small-angle neutron scattering (CV-SANS). We had SANS measurement of the CHP nanogel dispersed in complex solvent of DO/HO to clarify the microscopic structure of cross-linking domain. The result shows that the particle radius of the pullulan and the cholesterol are 8.09 and 6.31 nm, respectively. The dispersion of the cross-linking domains might have important implications for the interactions of nanogels with other molecules.
Sekine, Yurina; Endo, Hitoshi*; Iwase, Hiroki*; Takeda, Shigeo*; Mukai, Sadaatsu*; Fukazawa, Hiroshi; Sasaki, Yoshihiro*; Akiyoshi, Kazunari*
no journal, ,
Cholesterol-bearing pullulan (CHP) forms stable nanogel of 20 nm in size in water. The CHP nanogels can trap various proteins spontaneously. Owing to their characteristics, nanogels can be used in protein delivery systems, particularly for cancer vaccines. The spatial distribution and detailed structure of the cross-linking points are important factor determining their chemical and physical functions. The aim of this study is to investigate the structure of the nanogels by means of contrast variation small-angle neutron scattering (CV-SANS), which enables us to determine quantitative complex structure at nanometer scale. In this presentation, we will discuss the detailed structure of the CHP nanogel.
