A Simplified Cluster Analysis of Electron Track Structure for Estimating Complex DNA Damage Yields

Matsuya, Yusuke; Nakano, Toshiaki*; Kai, Takeshi; Shikazono, Naoya*; Akamatsu, Ken*; Yoshii, Yuji*; Sato, Tatsuhiko

International Journal of Molecular Sciences (Internet), 21(5), p.1701_1 - 1701_13, 2020/03

https://doi.org/10.3390/ijms21051701

Among various DNA damage induced after irradiation, clustered damage composed of at least two vicinal lesions within from 10 to 20 base pairs is recognized as fatal damage to human tissue. Such clustered damage yields have been evaluated by means of computational approaches; however, the simulation validity has not been sufficiently made yet. Meanwhile, the experimental technique to detect clustered DNA damage has been evolved in the recent decades, so both approaches with simulation and experiment get used to be available for investigating clustered damage recently. In this study, we have developed a simple model for estimating clustered damage yield based on the spatial density of ionization and electronic excitation events obtained by the PHITS code, and compared the computational results to the experimental clustered damage coupled with base damage (BD) measured by gel electrophoresis and atomic force microscopy. The computational results agreed well with experimental fractions of clustered damage of strand breaks (SB) and BD, when the yield ratio of BD/SSB is assumed to be 1.3. From the comparison of complex DNA double-strand break coupled with BDs between simulation and experimental data, it was suggested that aggregation degree of the events along electron track reflects the complexity of DNA damage. The resent simulation enables to quantify the type of clustered damage which cannot be measured in in vitro experiment, which succeeded in interpreting the experimental detection efficiency for clustered BD.

Analysis of tungsten transport in JT-60U plasmas

Shimizu, Yusuke*; Fujita, Takaaki*; Arimoto, Hideki*; Nakano, Tomohide; Hoshino, Kazuo; Hayashi, Nobuhiko

Plasma and Fusion Research (Internet), 10(Sp.2), p.3403062_1 - 3403062_4, 2015/07

https://doi.org/10.1585/pfr.10.3403062

Synchrotron radiation photoelectron spectroscopy study of thermally grown oxides on 4H-SiC(0001) Si-face and (000-1) C-face substrates

Watanabe, Heiji*; Hosoi, Takuji*; Kirino, Takashi*; Uenishi, Yusuke*; Chanthaphan, A.*; Yoshigoe, Akitaka; Teraoka, Yuden; Mitani, Shuhei*; Nakano, Yuki*; Nakamura, Takashi*; et al.

Materials Science Forum, 717-720, p.697 - 702, 2012/05

https://doi.org/10.4028/www.scientific.net/MSF.717-720.697

Deuteron-production double-differential cross sections for 300- and 392-MeV proton-induced reactions deduced from experiment and model calculation

Uozumi, Yusuke*; Sawada, Yusuke*; Mzhavia, A.*; Nogamine, Sho*; Iwamoto, Hiroki; Kin, Tadahiro; Hohara, Shinya*; Wakabayashi, Genichiro*; Nakano, Masahiro*

Physical Review C, 84(6), p.064617_1 - 064617_11, 2011/12

https://doi.org/10.1103/PhysRevC.84.064617

Deuteron production from intermediate-energy proton-nucleus interactions was investigated through experiments and model calculations, mainly to develop a theoretical model by elucidating the mechanism of cluster production. Spectral double-differential cross sections were measured for inclusive (, ) reactions on five targets in the periodic table, namely C, Al, V, Nb, and Au, at beam energies of 300 and 392 MeV. The cross sections were determined in almost the entire outgoing energy range from the highest down to 30 MeV and at laboratory angles from 20 to 104. To interpret the measured spectra, we proposed a new model that includes the nucleon correlations of the initial- and final-state interactions to describe cluster knockout and pickup within the intranuclear cascade model. The results of the model calculations showed reasonable agreements with those of the experiments. Moreover, the model indicated reasonable predictive power for the (, He), (, ), and (, ) reactions measured elsewhere.

Identified charged hadron production in collisions at = 200 and 62.4 GeV

Adare, A.*; Afanasiev, S.*; Aidala, C.*; Ajitanand, N. N.*; Akiba, Yasuyuki*; Al-Bataineh, H.*; Alexander, J.*; Aoki, Kazuya*; Aphecetche, L.*; Armendariz, R.*; et al.

Physical Review C, 83(6), p.064903_1 - 064903_29, 2011/06

https://doi.org/10.1103/PhysRevC.83.064903

Transverse momentum distributions and yields for , and in collisions at = 200 and 62.4 GeV at midrapidity are measured by the PHENIX experiment at the RHIC. We present the inverse slope parameter, mean transverse momentum, and yield per unit rapidity at each energy, and compare them to other measurements at different collisions. We also present the scaling properties such as and scaling and discuss the mechanism of the particle production in collisions. The measured spectra are compared to next-to-leading order perturbative QCD calculations.

Azimuthal correlations of electrons from heavy-flavor decay with hadrons in and Au+Au collisions at = 200 GeV

Adare, A.*; Afanasiev, S.*; Aidala, C.*; Ajitanand, N. N.*; Akiba, Yasuyuki*; Al-Bataineh, H.*; Alexander, J.*; Aoki, Kazuya*; Aphecetche, L.*; Aramaki, Y.*; et al.

Physical Review C, 83(4), p.044912_1 - 044912_16, 2011/04

https://doi.org/10.1103/PhysRevC.83.044912

Measurements of electrons from the decay of open-heavy-flavor mesons have shown that the yields are suppressed in Au+Au collisions compared to expectations from binary-scaled collisions. Here we extend these studies to two particle correlations where one particle is an electron from the decay of a heavy flavor meson and the other is a charged hadron from either the decay of the heavy meson or from jet fragmentation. These measurements provide more detailed information about the interaction between heavy quarks and the quark-gluon matter. We find the away-side-jet shape and yield to be modified in Au+Au collisions compared to collisions.

Gate stack technologies for SiC power MOSFETs

Watanabe, Heiji*; Hosoi, Takuji*; Kirino, Takashi*; Uenishi, Yusuke*; Chanthaphan, A.*; Ikeguchi, Daisuke*; Yoshigoe, Akitaka; Teraoka, Yuden; Mitani, Shuhei*; Nakano, Yuki*; et al.

ECS Transactions, 41(3), p.77 - 90, 2011/00

https://doi.org/10.1149/1.3633023

Thermo-responsive extraction of cadmium(II) ion with TPEN-NIPA gel; Effect of the number of polymerizable double bond toward gel formation and the extracting behavior

Fukuoka, Sachio*; Kida, Tatsuya*; Nakajima, Yasutaka*; Tsumagari, Takayuki*; Watanabe, Wataru*; Inaba, Yusuke*; Mori, Atsunori*; Matsumura, Tatsuro; Nakano, Yoshio*; Takeshita, Kenji*

Tetrahedron, 66(9), p.1721 - 1727, 2010/02

https://doi.org/10.1016/j.tet.2009.12.047

N,N,N',N'-(tetrakis-2-pyridylmethyl)ethylenediamine (TPEN) derivatives bearing the different number (1-4) of a double bond moiety on the pyridine ring are synthesized and subjected to copolymerization with N-isopropylacrylamide in the presence of AIBN. The obtained poly(TPEN-NIPA)gels show thermo-responsive swelling/shrinking behaviors and are employed for the extraction of cadmium(II) ion from the aqueous solution to examine the relationship of the gel characteristics and the extraction performance. The polymer gels composed of the TPEN derivative bearing three or four double bonds exhibit temperature-dependent change of swelling and shrinking in water. These gels extract CdII ion efficiently from the aqueous solution in the swelling state at 5C, while little extraction was observed at 45C with shrinking.

Two-body Coulomb explosion and hydrogen migration in methanol induced by intense 7 and 21 fs laser pulses

Itakura, Ryuji; Liu, P.*; Furukawa, Yusuke*; Okino, Tomoya*; Yamanouchi, Kaoru*; Nakano, Hidetoshi*

Journal of Chemical Physics, 127(10), p.104306_1 - 104306_5, 2007/09

https://doi.org/10.1063/1.2768958

Coulomb explosion of methanol induced by intense laser pulses with t = 7 and 21 fs is investigated by coincidence momentum imaging. When t = 7, the angular distribution of recoil vectors for the direct C-O bond breaking exhibits a peak deflected from the laser polarization direction by 30-45 deg., and the corresponding angular distribution for the migration pathway exhibits almost the same profile. When the laser pulse is stretched to t = 21 fs, the angular distributions for the direct and migration pathways exhibit a broad peak along the laser polarization direction. However, the extent of the anisotropy in the migration pathway is smaller than that in the direct pathway, exhibiting a substantial effect of hydrogen atom migration.

Redeposition distribution of tungsten eroded from the tungsten coated divertor tiles in JT-60U

Fukumoto, Masakatsu*; Otsuka, Yusuke*; Ueda, Yoshio*; Tanabe, Tetsuo*; Sakasai, Akira; Masaki, Kei; Arai, Takashi; Yagyu, Junichi; Nobuta, Yuji; Kubo, Hirotaka; et al.

no journal, , 

no abstracts in English