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Nishinaka, Ichiro; Yokoyama, Akihiko*; Washiyama, Koshin*; Maeda, Eita*; Watanabe, Shigeki; Hashimoto, Kazuyuki; Ishioka, Noriko; Makii, Hiroyuki; Toyoshima, Atsushi; Yamada, Norihiro*; et al.
Journal of Radioanalytical and Nuclear Chemistry, 304(3), p.1077 - 1083, 2015/06
Times Cited Count:9 Percentile:60.64(Chemistry, Analytical)Production cross sections of astatine isotopes At in the 29-57 MeV Li induced reaction with Pb target have been measured by - and -ray spectrometry. Excitation functions of production cross sections have been compared with a statistical model calculation to study the reaction mechanism of Li + Pb. Considerably small experimental cross sections of At and At compared with the calculation were clearly observed at incident energies higher than 44 MeV, indicating that the effects of breakup reaction play a role. A chemical separation of astatine from an irradiated lead target has been studied with a dry-distillation method. A complementary way to produce astatine isotopes has been developed.
Kaneko, Hirohisa; Hanaya, Hiroaki; Haneda, Noriyuki; Yamagata, Ryohei; Seito, Hajime; Kanazawa, Takao; Kojima, Takuji; Koyama, Shigeru*; Yamaguchi, Toshiyuki*; Kawashima, Ikuo*; et al.
JAEA-Review 2007-060, JAEA Takasaki Annual Report 2006, P. 209, 2008/03
The accelerator served mainly for graft-polymerization for new material development, radiation effect study on semiconductors, and various experiments of outside users. The annual operation time for the electron accelerator is 597.4h(517h for vertical beams, 80.4h for horizontal beams) The Co-60 -ray irradiation facilities consist of three buildings (8 rooms) and cover a wide dose-rate range from 0.04Gy/h to 20kGy/h with eight irradiation cells. The annual operation time for the cobalt first, second irradiation facilities and food irradiation facility is 20,844 h, 6,335 h and 3,150 h.
Kojima, Takuji; Kaneko, Hirohisa; Haneda, Noriyuki; Hanaya, Hiroaki; Yamagata, Ryohei; Seito, Hajime; Kanazawa, Takao; Koyama, Shigeru*; Yamaguchi, Toshiyuki*; Kawashima, Ikuo*; et al.
JAEA-Review 2007-060, JAEA Takasaki Annual Report 2006, P. 208, 2008/03
An electron accelerator and three ray irradiation facilities were operated for various research subjects as operation plan in FY 2006 without serious trouble. The number of research subjects for the No.1 accelerator, the Cobalt No.1 facility, the Cobalt No.2 facility, and the Food irradiation facility, is 544, 159, 622, and 357, respectively.
Kanazawa, Takao; Kaneko, Hirohisa; Haneda, Noriyuki; Hanaya, Hiroaki; Yamagata, Ryohei; Seito, Hajime; Koyama, Shigeru*; Yamaguchi, Toshiyuki*; Kawashima, Ikuo*; Yagi, Norihiko*; et al.
JAEA-Review 2006-042, JAEA Takasaki Annual Report 2005, P. 200, 2007/02
An electron accelerator and three ray irradiation facilities were operated without any trouble for various experiments in FY 2005. The operation of No.2 accelerator was terminated at April 2005. The number of experimental subjects was 544 for the No.1 accelerator, 287 for the Cobalt No.1 facility, 630 for the Cobalt No.2 facility, and 339 for the Food irradiation facility.
Haneda, Noriyuki; Yamagata, Ryohei; Kaneko, Hirohisa; Hanaya, Hiroaki; Seito, Hajime; Kanazawa, Takao; Koyama, Shigeru*; Kawashima, Ikuo*; Yagi, Norihiko*; Takagi, Masahide*; et al.
JAEA-Review 2006-042, JAEA Takasaki Annual Report 2005, P. 202, 2007/02
The Co-60 -ray irradiation facilities consist of three buildings and cover a wide dose-rate range from 0.04Gy/h to 20kGy/h with eight irradiation cells. All the facilities have been operated without serious trouble and served for the following various R&D's of JAEA and out side users such as development of new materials, radiation resistance test, radiation biotechnology.
Sakurai, Eiko*; Yanai, Kazuhiko*; Ishii, Keizo*; Oyama, Ryohei*; Sakamaki, Manabu*; Yamanaka, Kentaro*; Yamazaki, Hiromichi*; Matsuyama, Shigeo*; Kamiya, Tomihiro; Sato, Takahiro; et al.
no journal, ,
no abstracts in English
Nishinaka, Ichiro; Yokoyama, Akihiko*; Washiyama, Koshin*; Amano, Ryohei*; Yamada, Norihiro*; Ishiguro, Rika*; Makii, Hiroyuki; Hashimoto, Kazuyuki
no journal, ,
An radioactive nuclide At is a prospective candidate for utilization in targeted alpha radiotherapy. We have started nuclear and radiochemical study of production and utilization of radioactive astatine isotopes using lithium ion beams at the tandem accelerator of JAEA-Tokai. We determined the excitation functions of astatine isotopes in the reaction of 29-48 MeV Li+Pb and studied a chemical behavior of carrier-free radioactive astatine isotopes with a dry-chemistry method. Details will be shown in the presentation.
Nishinaka, Ichiro; Yokoyama, Akihiko*; Washiyama, Koshin*; Amano, Ryohei*; Ri, Keiko*; Yamada, Norihiro*; Ishiguro, Rika*; Maeda, Eita*; Makii, Hiroyuki; Hashimoto, Kazuyuki; et al.
no journal, ,
We have started to study production and utilization of an radioactive nuclide At which is a prospective candidate for targeted alpha radiotherapy. We determined production cross sections of astatine radioisotopes in the reaction of 29-48 MeV Li+Pb by -ray and -ray spectrometry at the tandem accelerator of JAEA-Tokai. Besides, we developed a simple dry-chemical method for separation of astatine.
Nishinaka, Ichiro; Yokoyama, Akihiko*; Washiyama, Koshin*; Amano, Ryohei*; Maeda, Eita*; Yamada, Norihiro*; Makii, Hiroyuki; Watanabe, Shigeki; Ishioka, Noriko; Hashimoto, Kazuyuki
no journal, ,
Nishinaka, Ichiro; Makii, Hiroyuki; Toyoshima, Atsushi; Yokoyama, Akihiko*; Washiyama, Koshin*; Amano, Ryohei*; Maeda, Eita*; Yamada, Norihiro*; Taniguchi, Takumi*; Watanabe, Shigeki; et al.
no journal, ,
no abstracts in English
Nishinaka, Ichiro; Yokoyama, Akihiko*; Washiyama, Koshin*; Amano, Ryohei*; Maeda, Eita*; Yamada, Norihiro*; Makii, Hiroyuki; Toyoshima, Atsushi; Watanabe, Shigeki; Ishioka, Noriko; et al.
no journal, ,
Production cross sections of astatine in 29-57 MeV Li + Pb have been measured by - and -ray spectrometry. Excitation functions of production cross sections have been compared with a statistical model calculation to study the reaction mechanism of the Li + Pb reaction. It indicates that the breakup of Li plays a rule in the Li + Pb reaction. Besides, we have developed a dry-distillation method which separates carrier-free astatine from an irradiated lead target.
Nishinaka, Ichiro; Yokoyama, Akihiko*; Washiyama, Koshin*; Amano, Ryohei*; Maeda, Eita*; Yamada, Norihiro*; Makii, Hiroyuki; Toyoshima, Atsushi; Watanabe, Shigeki; Ishioka, Noriko; et al.
no journal, ,
To promote utilization of a radioactive nuclide At which draws increasing attention as a promissing -emitter for targeted alpha therapy, we have measured production cross sections of astatine isotopes in the 29-57 MeVLi+Pb reaction using the tandem accelerator of JAEA-Tokai, providing nuclear data for production. For pharmaceutical study and so on, beside, we have developed a new separation procedure based on a dry-distillation method which separates carrier free astatine isotopes from lead targets with high radiochemical and chemical purity and high yields.
Nishinaka, Ichiro; Yokoyama, Akihiko*; Washiyama, Koshin*; Amano, Ryohei*; Maeda, Eita*; Taniguchi, Takumi*; Murakami, Kento*; Watanabe, Shigeki; Suzuki, Hiroyuki; Ishioka, Noriko; et al.
no journal, ,
In general, an -emitter At which is a prospective candidate for utilization in targeted alpha radiotherapy is produced through the Bi(He, 2n)At reaction. In contrast, our project is focusing on the production in the Bi(Li, 5n)Rn reaction. This enables us to supply At in a Rn/At generator system. The daughter At (7.2 h half-life) is extracted from the parent Rn (14h), expanding time-frame for transportation and use of At. To use astatine and iodine radioisotopes in our project, the excitation functions of Bi(Li, xn)Rn, Pb(Li, xn)At and Sn(Li, xn)I reactions have been measured. In addition to that, separation techniques have been developed. We report not only on the production and separation of astatine and iodine radioisotopes in the reactions but also on the utilization of those radioisotopes.
Washiyama, Koshin*; Maeda, Eita*; Yokoyama, Akihiko*; Nishinaka, Ichiro; Taniguchi, Takumi*; Yamada, Norihiro*; Makii, Hiroyuki; Toyoshima, Atsushi; Amano, Ryohei*
no journal, ,
A Rn/At generator for targeted alpha therapy has been developed.
Washiyama, Koshin*; Amano, Ryohei*; Maeda, Eita*; Yokoyama, Akihiko*; Nishinaka, Ichiro; Takahashi, Naruto*; Shinohara, Atsushi*; Watanabe, Shigeki; Ishioka, Noriko
no journal, ,
In order to use of an alpha emitter for targeted alpha therapy, we have started the production and the utilization of At using 30 MeV He particle in the Bi(He, 2n)At nuclear reaction at cyclotron facilities of Osaka University and JAEA Takasaki. In addition to that, we have been developing a Rn/At generator to expand the availability of At to wide range of populations far away from cyclotron facilities. The results of studies on the At-chemistry for clinical use and on the development of the Rn/At generator will be presented. And a review of current status of targeted alpha therapy in Japan will be also introduced.