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Awual, M. R.; Rahman, I. M. M.*; Yaita, Tsuyoshi; Khaleque, M. A.*; Ferdows, M.*
Chemical Engineering Journal, 236, p.100 - 109, 2014/01
Times Cited Count:344 Percentile:99.59(Engineering, Environmental)Rahman, I. M. M.*; Begum, Z. A.*; Salehi Lisar, S. Y.*; Motafakkerazad, R.*; Awual, M. R.; Hasegawa, Hiroshi*
Arsenic; Detection, Management Strategies and Health Effects, p.117 - 129, 2014/00
Hidaka, Koshi*; Kimura, Toru*; Abdel-Rahman, H. M.*; Nguyen, J.-T.*; McDaniel, K. F.*; Kohlbrenner, W. E.*; Molla, A.*; Adachi, Motoyasu; Tamada, Taro; Kuroki, Ryota; et al.
Journal of Medicinal Chemistry, 52(23), p.7604 - 7617, 2009/07
Times Cited Count:19 Percentile:44.62(Chemistry, Medicinal)A series of HIV protease inhibitor based on the allophenylnorstatine structure with various P2' moieties were synthesized. Among these analogues, we discovered that a small allyl group would maintain potent enzyme inhibitory activity compared to that of the -methylbenzyl moiety in clinical candidate 1 (KNI-764, also known as JE-2147, AG-1776 or SM-319777). Introduction of an anilinic amino group to 2 (KNI-727) improved water-solubility and anti-HIV-1 activity. X-ray crystallographic analysis of 13k (KNI-1689) with a -methallyl group at P2' position revealed hydrophobic interactions with Ala28, Ile84, and Ile50' similar to that of 1. The presence of an additional methyl group on the allyl group in compound 13k significantly increased anti-HIV activity over 1, while providing a rational drug design for structural minimization and improving membrane permeability.
Koarashi, Jun; Saito, Fumihiro; Akiyama, Kiyomitsu; Rahman, N. M.*; Iida, Takao*
Applied Radiation and Isotopes, 65(4), p.413 - 418, 2007/04
Times Cited Count:33 Percentile:89.01(Chemistry, Inorganic & Nuclear)no abstracts in English
Rahman, N. M.*; Iida, Takao*; Saito, Fumihiro; Koarashi, Jun; Yamasaki, Keizo*; Yamazawa, Hiromi*; Moriizumi, Jun*
Radiation Protection Dosimetry, 123(2), p.171 - 181, 2007/02
Times Cited Count:11 Percentile:61(Environmental Sciences)no abstracts in English
Rahman, M.*; Suzaki, Takenori; Mori, Takamasa
JAERI-Research 2003-007, 68 Pages, 2003/03
no abstracts in English
Koarashi, Jun; Saito, Fumihiro; Akiyama, Kiyomitsu; Iida, Takao*; Rahman, N. M.*
no journal, ,
no abstracts in English
Koarashi, Jun; Saito, Fumihiro; Akiyama, Kiyomitsu; Rahman, N. M.*; Iida, Takao*
no journal, ,
no abstracts in English
Yamasaki, Keizo*; Oki, Yuichi*; Osada, Naoyuki*; Yokoyama, Sumi; Yamada, Yuji*; Tokonami, Shinji*; Fukutsu, Kumiko*; Iida, Takao*; Rahman, N. M.*; Shimo, Michikuni*
no journal, ,
no abstracts in English
Honda, Maki; Martschini, M.*; Steier, P.*; Golser, R.*; Kanivets, V.*; Rahman, I. M. M.*; Yamasaki, Shinya*; Sakaguchi, Aya*
no journal, ,
A new analytical method for Sr utilizing accelerator mass spectrometry (AMS) achieved better detection limits (1/10 of 0.1 mBq) than conventional -ray detection methods. In order to demonstrate the applicability of the AMS method to environmental samples of various properties, the present study analyzed impurity-rich water samples collected from the cooling water supply ponds of the Chornobyl NPP. The Sr/Sr atomic ratio of the water samples (evaluated by -ray detection and ICP-MS), the expected detection limit, and the analysis method are reported in this meeting. Furthermore, the adaptability of the AMS method for Sr concentration (Bq/L) in water samples will be demonstrated by comparing the AMS method with the -ray detection method.