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Nagai, Yasuki*; Kawabata, Masako*; Hashimoto, Shintaro; Tsukada, Kazuaki; Hashimoto, Kazuyuki*; Motoishi, Shoji*; Saeki, Hideya*; Motomura, Arata*; Minato, Futoshi; Ito, Masatoshi*
Journal of the Physical Society of Japan, 91(4), p.044201_1 - 044201_10, 2022/04
Times Cited Count:0 Percentile:48.58(Physics, Multidisciplinary)Recently, Lu is considered as one of the most important medical RIs for treating neuroendocrine tumors. A plan to produce Lu with high purity by using enriched Yb samples with irradiation of deuteron beams in accelerators has been discussed. However, since the other Yb isotopes contained in the Yb sample interacts with deuterons, Lu isotopes other than Lu are produced as impurities. Since the purity of Lu is important for medical use, a method to evaluate the impurity of Lu has been required. In this study, we proposed a new method to estimate production yields of each Lu isotopes in Yb samples with arbitrary isotopic compositions by using excitation functions of Yb()Lu reactions and the particle transport calculation code PHITS. The method plays an important role in discussing the isotopic composition of enriched samples to produce high-purity Lu using accelerators.
Kawabata, Masako*; Motoishi, Shoji*; Ota, Akio*; Motomura, Arata*; Saeki, Hideya*; Tsukada, Kazuaki; Hashimoto, Shintaro; Iwamoto, Nobuyuki; Nagai, Yasuki*; Hashimoto, Kazuyuki*
Journal of Radioanalytical and Nuclear Chemistry, 330(3), p.913 - 922, 2021/12
Times Cited Count:4 Percentile:73.26(Chemistry, Analytical)Both Cu and Cu are promising radionuclides in nuclear medicine. Production yields of these radionuclides were quantified by irradiating 55.4 g of natural zinc with accelerator neutrons. Clinically suitable Cu and Cu yields were estimated by experimental based numerical simulations using 100 g of enriched Zn and Zn, respectively, and elevated neutron fluxes from 40 MeV, 2 mA deuterons. A combined thermal- and resin-separation method was developed to isolate Cu and Cu from zinc, resulting in 73% separation efficiency and 97% zinc recovery. Such methods can provide large scale production of Cu and Cu for clinical applications.
Tsukada, Kazuaki; Nagai, Yasuki*; Hashimoto, Shintaro; Minato, Futoshi; Kawabata, Masako*; Hatsukawa, Yuichi*; Hashimoto, Kazuyuki*; Watanabe, Satoshi*; Saeki, Hideya*; Motoishi, Shoji*
Journal of the Physical Society of Japan, 89(3), p.034201_1 - 034201_7, 2020/03
Times Cited Count:2 Percentile:22.58(Physics, Multidisciplinary)We found anomalously large yields of Ga, Ga, Zn and Cu by neutron irradiation on a ZnO sample in a polyethylene shield. Neutron beams are generated from the Be() reaction for 50 MeV deuterons. The yields obtained were more than 20 times larger than those in the unshielded sample. On the other hand, the yields of Ga, Ga, Zn and Cu from a metallic Zn sample and the yields of Cu, Ni and Zn from the ZnO and Zn samples were almost insensitive to the shield conditions. This finding would provide us a unique capability of accelerator neutrons to simultaneously produce a large amount of several radioisotopes, including proton induced reaction products, by using a single sample. The experimental data were compared with the yields estimated by using the Particle and Heavy Ion Transport code System and the result was discussed.
Tsukada, Kazuaki; Nagai, Yasuki*; Hashimoto, Kazuyuki*; Kawabata, Masako*; Minato, Futoshi; Saeki, Hideya*; Motoishi, Shoji*; Ito, Masatoshi*
Journal of the Physical Society of Japan, 87(4), p.043201_1 - 043201_5, 2018/04
Times Cited Count:9 Percentile:60.59(Physics, Multidisciplinary)Minato, Futoshi; Tsukada, Kazuaki; Sato, Nozomi*; Watanabe, Satoshi*; Saeki, Hideya*; Kawabata, Masako*; Hashimoto, Shintaro; Nagai, Yasuki*
Journal of the Physical Society of Japan, 86(11), p.114803_1 - 114803_6, 2017/11
Times Cited Count:8 Percentile:57.21(Physics, Multidisciplinary)We have measured the yield of Mo, the mother nuclide of Tc used in nuclear diagnostic procedure. Mo was produced by Mo(,)Mo using neutrons with thermal energy up to about 40 MeV, provided by C(,). The Mo yield agrees with an estimated yield with the use of the latest data of C(,) and the evaluated cross section given in the JENDL. Based on this, a new calculation was carried out to produce Mo to seek for a good economical condition. Various conditions such as the MoO sample mass, the distance between the carbon target and the sample, the radius of the deuteron beam, and the neutron irradiation time were considered. The calculated Mo yield indicates that about 30% of the Mo demand in Japan can be fulfilled with a single accelerator. The elusion of Tc from the Mo twice per day would meet about 50% of the Mo demand.
Sugo, Yumi*; Hashimoto, Kazuyuki*; Kawabata, Masako*; Saeki, Hideya*; Sato, Shunichi*; Tsukada, Kazuaki; Nagai, Yasuki*
Journal of the Physical Society of Japan, 86(2), p.023201_1 - 023201_3, 2017/02
Times Cited Count:13 Percentile:68.41(Physics, Multidisciplinary)Cu produced by the Zn()Cu reaction was used for the first time to determine the biodistribution of CuCl in colorectal tumor-bearing mice. High uptake of Cu was observed in the tumor as well as in the liver and kidney which are the major organs for copper metabolism. The result showing Cu accumulation in the tumor suggests that CuCl can be a potential radionuclide agent for cancer radiotherapy. It would also encourage further studies on the therapeutic effect in small animals using an increased dose of Cu produced by the Zn()Cu reaction using intense neutrons available at present.
Hashimoto, Kazuyuki; Nagai, Yasuki; Kawabata, Masako; Sato, Nozomi*; Hatsukawa, Yuichi; Saeki, Hideya; Motoishi, Shoji*; Ota, Masayuki; Konno, Chikara; Ochiai, Kentaro; et al.
Journal of the Physical Society of Japan, 84(4), p.043202_1 - 043202_4, 2015/04
Times Cited Count:7 Percentile:53.16(Physics, Multidisciplinary)Kawabata, Masako; Nagai, Yasuki; Hashimoto, Kazuyuki; Saeki, Hideya; Motoishi, Shoji*; Sato, Nozomi*; Ota, Akio*; Shiina, Takayuki*; Kawauchi, Yukimasa*
Journal of the Physical Society of Japan, 84(2), p.023201_1 - 023201_4, 2015/02
Times Cited Count:6 Percentile:45.45(Physics, Multidisciplinary)Tc for medical use can be separated by thermochromatography from a molten MoO sample. Effect of moist oxygen gas on the Tc release from molten MoO samples was investigated using a Mo/Tc generator. Mo was produced with Mo(n,2n)Mo. A new phenomenon has been observed: release rate, separation- and recovery-efficiencies of Tc were higher in the moist oxygen gas than those in the dry oxygen gas. The present result is a significant progress towards the stable production of a high quality Tc from a molten MoO sample with high separation efficiency. The result would also give us a new insight into the interaction between the moist oxygen gas and the molten MoO.
Sato, Nozomi; Tsukada, Kazuaki; Watanabe, Satoshi; Ishioka, Noriko; Kawabata, Masako; Saeki, Hideya; Nagai, Yasuki; Kin, Tadahiro*; Minato, Futoshi; Iwamoto, Nobuyuki; et al.
Journal of the Physical Society of Japan, 83(7), p.073201_1 - 073201_4, 2014/07
Times Cited Count:13 Percentile:64.28(Physics, Multidisciplinary)We have for the first time demonstrated that the therapeutic nuclide of Cu produced by Zn(,)Cu has highest radionuclide purity compared to previous ones. We measured a -ray spectrum of the reaction product produced by bombarding an enriched Zn sample with neutrons with a HPGe detector. The neutrons were obtained by C(,) using 41 MeV deuterons provided from Takasaki Ion Accelerators for Advanced Radiation Application of Japan Atomic Energy Agency. Relative production yields of impurity radionuclides such as Zn to Cu are extremely low, which allow us to chemically separate Cu from an irradiated Zn sample with a few steps and to reuse high cost an enriched Zn sample. The present result strongly suggest that the Zn(,)Cu reaction is the most promising route to produce high quality Cu and could solve a longstanding problem of establishing an appropriate production method of Cu.
Nagai, Yasuki; Kawabata, Masako; Sato, Nozomi; Hashimoto, Kazuyuki; Saeki, Hideya; Motoishi, Shoji*
Journal of the Physical Society of Japan, 83(8), p.083201_1 - 083201_4, 2014/07
Times Cited Count:10 Percentile:58.02(Physics, Multidisciplinary)Nagai, Yasuki; Hashimoto, Kazuyuki; Hatsukawa, Yuichi; Saeki, Hideya; Motoishi, Shoji; Sonoda, Nozomi; Kawabata, Masako; Harada, Hideo; Kin, Tadahiro*; Tsukada, Kazuaki; et al.
Journal of the Physical Society of Japan, 82(6), p.064201_1 - 064201_7, 2013/06
Times Cited Count:41 Percentile:85.16(Physics, Multidisciplinary)Motoishi, Shoji; Kobayashi, Katsutoshi; Saeki, Hideya*
JAERI-Tech 2000-070, 34 Pages, 2000/12
no abstracts in English
Hashimoto, Kazuyuki; Motoishi, Shoji; Saeki, Hideya*; Sorita, Takami; Matsuoka, Hiromitsu
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no abstracts in English
Hashimoto, Kazuyuki; Motoishi, Shoji*; Saeki, Hideya*; Sorita, Takami; Matsuoka, Hiromitsu
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Rhenium-188 is a useful generator-produced radioisotope for therapeutic applications because of their energetic beta particles and rays suitable for imaging. Because the W parent is obtained in a relatively low specific activity from the irradiation of enriched W in a reactor, relatively large volumes of normal saline are required to elute the Re from alumina based W/Re generators. In this study, a simple apparatus for effective concentrations of 188Re solutions from alumina-based W/Re generators was developed by a tandem cation-anion column system. Concentration ratios greater than 50:1 can be achieved with this apparatus.
Tsukada, Kazuaki; Sato, Nozomi; Watanabe, Satoshi; Ishioka, Noriko; Hatsukawa, Yuichi; Hashimoto, Kazuyuki; Kin, Tadahiro*; Kawabata, Masako; Saeki, Hideya; Nagai, Yasuki
no journal, ,
no abstracts in English
Kawabata, Masako; Hashimoto, Kazuyuki; Saeki, Hideya; Sato, Nozomi*; Motoishi, Shoji*; Nagai, Yasuki
no journal, ,
no abstracts in English
Nagai, Yasuki; Kawabata, Masako; Sato, Nozomi*; Hashimoto, Kazuyuki; Saeki, Hideya; Motoishi, Shoji*; Hatsukawa, Yuichi; Ota, Akio; Shiina, Takayuki; Kawauchi, Yukimasa
no journal, ,
Tc, the daughter nuclide of Mo, is widely used for medical diagnosis. In Japan, about 0.9 million diagnostic procedures are carried out using Tc. Mo has been mostly produced using U in research reactors. Because of recent shortages of Mo, a variety of alternative production methods of Mo or Tc were proposed. We proposed to produce Mo by Mo(n,2n) using neutrons from an accelerator. The route is characterized to produce a large quantity of high-quality Mo with a minimum level of radioactive wastes, since the cross section of the Mo(n,2n)Mo reaction at 11 En 18 MeV is large, and the cross sections of the (n,He), (n,n'p), and (n,p) reactions on Mo are quite small. Intense neutrons are available because of recent progresses of accelerator and target technologies. In the talk, we show our recent experimental results to obtain Tc with high-quality using Mo produced by Mo(n,2n).
Hashimoto, Kazuyuki; Kawabata, Masako; Saeki, Hideya; Tsukada, Kazuaki; Sato, Nozomi*; Motoishi, Shoji*; Nagai, Yasuki; Watanabe, Satoshi; Ishioka, Noriko
no journal, ,
Copper-67 is an attractive radionuclide for cancer therapy, because of emissions of medium energy particle (a mean energy of 141 keV) and rays (91, 93, 185 keV) suitable for imaging, and its appropriate half-life (62 hours). However, the use of Cu for clinical researches has been limited due to the difficulty in obtaining sufficient quantities. In this study, we have investigated the production of Cu by the Zn(n,x)Cu reaction (x = n'p, d) using fast neutrons from C(d,n) reaction. The highly purified Cu was obtained by the two columns separation method (chelate resin chelex-100 and anion exchange resin AG1-X8). Furthermore, the labelling of DOTA and TETA which are useful bifunctional ligands for the labelling monoclonal antibodies was succeeded in more than 97% yield.
Kawabata, Masako; Hashimoto, Kazuyuki; Saeki, Hideya; Tsukada, Kazuaki; Watanabe, Satoshi; Nagai, Yasuki
no journal, ,
Cu has being attracting attention as a potential candidate for radiopharmaceutical. A high-purity Cu can be isolated from an irradiated ZnO using fast neutrons generated via C(d,n) reaction with only a few RIs as side products. This study was aimed at achieving a higher purity for the final Cu by separating Ni amongst other side products. As a result Cu free from Ni was obtained with high radionuclide purity with minimum loss of time during the separation.
Hashimoto, Kazuyuki; Kawabata, Masako*; Saeki, Hideya*; Sato, Shunichi*; Tsukada, Kazuaki; Watanabe, Satoshi; Nagai, Yasuki
no journal, ,
no abstracts in English