Poro-elastic parameter acquisition test using siliceous mudstone (Wakkanai formation)

Aoki, Tomoyuki*; Tani, Takuya*; Sakai, Kazuo*; Koga, Yoshihisa*; Aoyagi, Kazuhei; Ishii, Eiichi

JAEA-Research 2020-002, 83 Pages, 2020/06

JAEA-Research-2020-002.pdf:8.25MB
JAEA-Research-2020-002-appendix(CD-ROM).zip:6.63MB

The Japan Atomic Energy Agency (JAEA) has conducted with the Horonobe Underground Research Project in Horonobe, Teshio-gun, Hokkaido for the purpose of research and development related to geological disposal technology for high-level radioactive wastes in sedimentary soft rocks. The geology around the Horonobe Underground Research Laboratory (HURL) is composed of the Koetoi diatomaceous mudstone layer and the Wakkanai siliceous layer, both of which contain a large amount of diatom fossils. Since these rocks exhibit relatively high porosity but low permeability, it is important to investigate the poro-elastic characteristics of the rock mass. For this objective, it is necessary to measure parameters based on the poro-elastic theory. However, there are few measurement results of the poro-elastic parameters for the geology around HURL, and the characteristics such as dependence on confining pressure are not clearly understood. One of the reasons is that the rocks show low permeability and the pressure control during testing is difficult. Therefore, a poro-elastic parameter measurement test was conducted on the siliceous mudstone of the Wakkanai formation to accumulate measurement results on the poro-elastic parameters and to examine the dependence of the parameters on confining pressure. As a result, some dependency of the poro-elastic parameters on confining pressure was observed. Among the measured or calculated poro-elastic parameters, the drained bulk modulus increased, while the Skempton's pressure coefficient, and the Biot-Wills coefficient in the elastic region decreased with the increase in confining pressure. The measurement results also inferred that the foliation observed in the rock specimens might impact a degree of dependency of those parameters on confining pressure.

Electromagnetic design of the prototype spoke cavity for the JAEA-ADS linac

Tamura, Jun; Kondo, Yasuhiro; Yee-Rendon, B.; Meigo, Shinichiro; Maekawa, Fujio; Hasegawa, Kazuo; Kako, Eiji*; Umemori, Kensei*; Sakai, Hiroshi*; Konomi, Taro*

Proceedings of 19th International Conference on RF Superconductivity (SRF 2019) (Internet), p.399 - 402, 2019/11

https://doi.org/10.18429/JACoW-SRF2019-TUP007

Detection of a gas region in a human body across a therapeutic carbon beam by measuring low-energy photons

Yamaguchi, Mitsutaka; Nagao, Yuto; Kawachi, Naoki; Sato, Takahiro; Fujimaki, Shu; Kamiya, Tomihiro; Torikai, Kota*; Shimada, Hirofumi*; Sugai, Hiroyuki*; Sakai, Makoto*; et al.

International Journal of PIXE, 26(1&2), p.61 - 72, 2016/00

https://doi.org/10.1142/S0129083516500078

no abstracts in English

Effect of swirl inflow on flow pattern and pressure fluctuation onto a single-elbow pipe in Japan Sodium-cooled Fast Reactor

Yamano, Hidemasa; Sago, Hiromi*; Hirota, Kazuo*; Hayakawa, Satoshi*; Xu, Y.*; Tanaka, Masaaki; Sakai, Takaaki

Journal of Fluid Science and Technology (Internet), 7(3), p.329 - 344, 2012/09

https://doi.org/10.1299/jfst.7.329

As part of the development of a flow-induced vibration evaluation methodology for the primary cooling piping in Japan Sodium-cooled Fast Reactor, important factors were discussed in evaluating the flow-induced vibration for the hot-leg piping. To investigate a complex flow near the inlet of the hot-leg piping, a reactor scale numerical analysis was carried out for the reactor upper plenum flow, which was simulated in a 1/10-scale reactor upper plenum experiment. Based on this analysis, experimental conditions on swirl inflow and deflected inflow that were identified as important factors were determined for flow-induced vibration experiments simulating only the hot-leg piping. In this study, the effect of the swirl inflow on flow pattern and pressure fluctuation onto the pipe wall was investigated in a 1/3-scale hot-leg pipe experiment. The experiment has indicated less significant for the pressure fluctuations, while the flow separation region was slightly influenced by the swirl flow. Computational fluid dynamics simulation results also appear in this paper, focusing on its applicability to the hot-leg piping experiments.

Quantitative analysis of cisplatin sensitivity of human esophageal squamous cancer cell lines using in-air micro-PIXE

Tanaka, Naritake*; Kimura, Hitoshi*; Faried, A.*; Sakai, Makoto*; Sano, Takaaki*; Inose, Takanori*; Soda, Makoto*; Okada, Koji*; Nakajima, Masanobu*; Miyazaki, Tatsuya*; et al.

Cancer Science, 101(6), p.1487 - 1492, 2010/06

https://doi.org/10.1111/j.1349-7006.2010.01542.x

We examined the intracellular localization of cisplatin, a key chemotherapeutic agent, in esophageal cancer cell lines and determined their sensitivity to cisplatin using in-air micro-PIXE. Two human esophageal squamous cell carcinoma (ESCC) cell lines, TE-2 and TE-13, were examined for their response to cisplatin using MTT assay, flow cytometry and DNA fragmentation assays. Real-time reverse transcription-polymerase chain reaction was also used to evaluate the mRNA expression of multidrug resistance protein 2 (MRP2) in both cell lines. Platinum localizations of intracellular and intranuclear were measured using in-air micro-PIXE. TE-2 cells were more sensitive to cisplatin than TE-13 cells. The results of this study suggest that in-air micro-PIXE could be a useful quantitative method for evaluating the cisplatin sensitivity of individual cells. Finally, we speculate that MRP2 in the cell membrane may play an important role in regulating cisplatin sensitivity of ESCC cells.

Subcellular changes of essential metal shown by in-air micro-PIXE in oral cadmium-exposed mice

Nakazato, Kyomi*; Nagamine, Takeaki*; Suzuki, Keiji*; Kusakabe, Takahiko*; Moon, H. D.*; Oikawa, Masakazu*; Sakai, Takuro; Arakawa, Kazuo

Biometals, 21(1), p.83 - 91, 2008/02

https://doi.org/10.1007/s10534-007-9095-6

To clarify the relation of essential metals to cadmium (Cd) toxicity, we evaluated metallothionein expression and analyzed the subcellular distribution of essential metals using in-air micro-PIXE. Four mice were dosed orally with 100 mg/L of Cd in drinking water for 1.5 or 2 years. Compared to the control, the Cd-exposed mice markedly accumulated zinc in the liver and renal cortex. Elemental maps showed that a large amount of Cd was spatially combined with zinc in the 1.5y-Cd mouse. The data suggest that zinc may contribute to protect against oral-administrated Cd toxicity.

Interferon-induced changes in metallothionein expression and subcellular distribution of zinc in HepG2 cells

Nagamine, Takeaki*; Kusakabe, Takahiko*; Takada, Hisashi*; Nakazato, Kyomi*; Sakai, Takuro; Oikawa, Masakazu*; Sato, Takahiro; Arakawa, Kazuo

Cytokine, 34(5-6), p.312 - 319, 2006/06

https://doi.org/10.1016/j.cyto.2006.06.008

no abstracts in English

Project of the JAERI superconducting AVF cyclotron for applications in biotechnology and materials science

Miyawaki, Nobumasa; Kurashima, Satoshi; Okumura, Susumu; Chiba, Atsuya; Agematsu, Takashi; Kamiya, Tomihiro; Kaneko, Hirohisa; Nara, Takayuki; Saito, Yuichi; Ishii, Yasuyuki; et al.

Proceedings of 17th International Conference on Cyclotrons and Their Applications (CYCLOTRONS 2004), p.208 - 210, 2005/00

A project to expand at TIARA (Takasaki Ion Accelerators for Advanced Radiation Application) facilities of JAERI has been proposed to broaden applications in biotechnology and materials science. Heavy ions with energy more than 100 MeV/n are required for remarkable progress in breeding of plant and development of new materials. The magnet of a superconducting AVF cyclotron with a K number of 900 has been designed to cope with acceleration of both 150 MeV/n heavy ions and 300 MeV protons. The lower limit of energies has been investigated to overlap the energy region covered by the JAERI AVF cyclotron, required to increase beam time for present users. We have designed a beam transport system to satisfy requirements of the applications.

Feasilibity study of the K900 superconducting AVF cyclotron for materials science and biotechnology

Fukuda, Mitsuhiro; Okumura, Susumu; Kurashima, Satoshi; Miyawaki, Nobumasa; Ishii, Yasuyuki; Saito, Yuichi; Mizuhashi, Kiyoshi; Agematsu, Takashi; Chiba, Atsuya; Sakai, Takuro; et al.

Proceedings of 1st Annual Meeting of Particle Accelerator Society of Japan and 29th Linear Accelerator Meeting in Japan, p.643 - 645, 2004/08

A superconducting AVF cyclotron with a bending limit of 900 MeV and a focusing limit of 300 MeV is being designed to meet the requirements for the research in materials science and biotechnology at TIARA facility of JAERI. The spiral-sector shape of the cyclotron magnet has been optimized for acceleration of a 300 MeV proton to produce sufficient focusing forces in an extraction region. An energy range of the superconducting AVF cyclotron overlaps with that of the present K110 JAERI AVF cyclotron. Characteristics of a resonator for the superconducting AVF cyclotron have been investigated using the MAFIA code. An acceleration voltage in a frequency range of 24 to 64 MHz can be produced by the resonator with a /2 excitation mode.

Development of a large-solid-angle and multi-device detection system for elemental analysis

Sato, Takahiro; Ishii, Keizo*; Kamiya, Tomihiro; Sakai, Takuro; Oikawa, Masakazu*; Arakawa, Kazuo; Matsuyama, Shigeo*; Yamazaki, Hiromichi*

Nuclear Instruments and Methods in Physics Research B, 210, p.113 - 116, 2003/09

https://doi.org/10.1016/S0168-583X(03)01053-X

A new detection apparatus for both low energy X-rays and back-scattered protons of MeV energy and its measurement system were developed. The detection apparatus consists of a multi-element detector, pre-amplifiers with active reset system and so on. The detector elements are arranged in the shape of a pentagonal pyramid and fully cover the sample. On each one detection side, 9 detector elements are arranged. The entire detection system consists thus of 45 detector elements. The micro-beam irradiates the sample through the center of the pentagonal pyramid and X-rays emitted from the sample are detected in close to geometry. This novel detection setup has about 10 times the sensitivity of a conventional Micro-PIXE camera. The counting rate of back-scattered protons per detection element is small despite lack of a passive absorber. It appears possible that X-rays from the very small quantity of elements could also be detected. The advantage over a conventional Micro-PIXE camera includes simultaneous detection of back-scattered protons from N, C and O.