Medical application of radiohalogenated peptides; Synthesis and evaluation of F(-I)KCCYSL for targeting HER2

Sasaki, Ichiro; Watanabe, Shigeki; Ohshima, Yasuhiro; Sugo, Yumi; Yamada, Keiichi*; Hanaoka, Hirofumi*; Ishioka, Noriko

Peptide Science 2015, p.243 - 246, 2016/03

Development of a widely usable amino acid tracer; Br--methyl-phenylalanine for tumor PET imaging

Hanaoka, Hirofumi*; Ohshima, Yasuhiro; Suzuki, Yurika*; Yamaguchi, Aiko*; Watanabe, Shigeki; Uehara, Tomoya*; Nagamori, Shushi*; Kanai, Yoshikatsu*; Ishioka, Noriko; Tsushima, Yoshito*; et al.

Journal of Nuclear Medicine, 56(5), p.791 - 797, 2015/05

https://doi.org/10.2967/jnumed.114.152215

Exploring of peptides with affinity to HER2 from random peptide libraries using radioisotope; Random hexapeptide libraries with fixed amino acid sequence at 1 and 2 positions

Sasaki, Ichiro; Hanaoka, Hirofumi*; Yamada, Keiichi*; Watanabe, Shigeki; Sugo, Yumi; Ohshima, Yasuhiro; Suzuki, Hiroyuki; Ishioka, Noriko

Peptide Science 2014, p.257 - 260, 2015/03

Full-coherent free electron laser seeded by 13th- and 15th-order harmonics of near-infrared femtosecond laser pulses

Sato, Takahiro*; Iwasaki, Atsushi*; Owada, Shigeki*; Yamanouchi, Kaoru*; Takahashi, Eiji*; Midorikawa, Katsumi*; Aoyama, Makoto; Yamakawa, Koichi; Togashi, Tadashi*; Fukami, Kenji*; et al.

Journal of Physics B; Atomic, Molecular and Optical Physics, 46(16), p.164006_1 - 164006_6, 2013/08

https://doi.org/10.1088/0953-4075/46/16/164006

By introducing 13th- (61.7 nm) and 15th-order harmonics (53.4 nm) of femtosecond laser pulses at 800 nm into an undulator of SCSS (SPring-8 Compact SASE Source) test accelerator at RIKEN, these harmonic pulses were amplified by a factor of more than 10 with a high contrast ratio through the interaction between accelerated electron bunches and the harmonic pulses. From numerical simulations of the amplification processes of high-order harmonic pulses in the undulator, optimum conditions of the electron bunch duration interacting with the high-order harmonic pulses were investigated for generating full-coherent and intense pulses in the extreme ultraviolet wavelength region.

Breakdown voltage in silicon carbide metal-oxide-semiconductor devices induced by ion beams

Oshima, Takeshi; Deki, Manato; Makino, Takahiro; Iwamoto, Naoya; Onoda, Shinobu; Hirao, Toshio*; Kojima, Kazutoshi*; Tomita, Takuro*; Matsuo, Shigeki*; Hashimoto, Shuichi*

AIP Conference Proceedings 1525, p.654 - 658, 2013/04

https://doi.org/10.1063/1.4802408

Metal-Oxide-Semiconductor (MOS) capacitors were fabricated on n-type 4H-SiC epitaxial layers, and the leakage current through the gate oxide during heavy ion irradiation was investigated in order to evaluate dielectric breakdown induced by heavy ions (Single Event Gate Rupture: SEGR). The gate oxide at thickness ranges between 60 and 80 nm was formed using pyrogenic oxidation at 1100 C for 60 min. Circular electrodes with 180 diameter were formed using Al evaporation and a lift-off technique. The leakage current observed through the gate oxide was monitored during 18 MeV oxygen (O) or nickel (Ni) ions. As a result, although no significant difference in the value of the electric field at the dielectric breakdown (around 8.2 MV/cm) was observed between non-irradiated and 18 MeV-O irradiated samples, the value decreased to be 7.3 MV/cm in the case of 18 MeV-Ni ion incidence. The Linier Energy Transfer (LET) for 18 MeV-O is 7 MeV cm/mg, and this value is smaller than that for 18 MeV-Ni (24 MeV cm/mg). Also, 18 MeV-Ni ions deposit energy in narrower regions than 18 MeV-O ions. Thus, it can be concluded that the high density of charge induced by 18 MeV-Ni ions triggers SEGR in SiC MOS capacitors.

Probing carbon edge exposure of iron phthalocyanine-based oxygen reduction catalysts by soft X-ray absorption spectroscopy

Niwa, Hideharu*; Saito, Makoto*; Kobayashi, Masaki*; Harada, Yoshihisa*; Oshima, Masaharu*; Moriya, Shogo*; Matsubayashi, Katsuyuki*; Nabae, Yuta*; Kuroki, Shigeki*; Ikeda, Takashi; et al.

Journal of Power Sources, 223, p.30 - 35, 2013/02

https://doi.org/10.1016/j.jpowsour.2012.09.031

To design non-platinum, inexpensive, but high performance carbon-based cathode catalysts for polymer electrolyte fuel cells, it is important to elucidate the active site for oxygen reduction reaction (ORR). However, it is difficult to directly identify the active site by applying conventional structural or electronic probes to such complex systems. Here, we used C 1 X-ray absorption spectroscopy (XAS) to observe electronic structure of carbon in iron phthalocyanine-based catalysts, and found a signature of edge exposure below the edge, whose intensity is well correlated with the ORR activity. These results demonstrate that C 1 XAS can be used to characterize the ORR activity of carbon-based cathode catalysts in terms of the edge exposure.

Development of a Br-labeled amino acid derivative for PET imaging of tumor

Hanaoka, Hirofumi*; Watanabe, Shigeki; Tominaga, Hideyuki*; Ohshima, Yasuhiro; Watanabe, Satoshi; Yamada, Keiichi*; Iida, Yasuhiko*; Ishioka, Noriko; Endo, Keigo*

JAEA-Review 2012-046, JAEA Takasaki Annual Report 2011, P. 89, 2013/01

https://jopss.jaea.go.jp/pdfdata/JAEA-Review-2012-046.pdf

no abstracts in English

Numerical experiments on dispersion of radionuclides in the ocean released from the Fukushima Daiichi Nuclear Power Plant

Kawamura, Hideyuki; Kobayashi, Takuya; Furuno, Akiko; In, Teiji*; Ishikawa, Yoichi*; Nakayama, Tomoharu*; Shima, Shigeki*; Awaji, Toshiyuki*

Reports of Research Institute for Applied Mechanics, Kyushu University, (143), p.111 - 117, 2012/09

Because of the Fukushima Dai-ichi Nuclear Power Plant disaster, some radionuclides were released into the ocean from the Fukushima Dai-ichi Nuclear Power Plant. In response to this situation, numerical experiments were carried out at Japan Atomic Energy Agency using an oceanic dispersion model and an ocean general circulation model to estimate an effect of the radionuclides on marine environment. It was suggested that the radionuclides deposited from the atmosphere mainly in the middle of March after the disaster spread over a comparatively wide area of the Pacific Ocean east of Japan. On the other hand the radionuclides directly released into the ocean from the Fukushima Dai-ichi Nuclear Power Plant were carried along the coast and then spread along the Kuroshio extension.

Terahertz absorption spectroscopy of protein-containing reverse micellar solution

Murakami, Hiroshi; Toyota, Yuji*; Nishi, Takaki*; Nashima, Shigeki*

Chemical Physics Letters, 519-520, p.105 - 109, 2012/01

https://doi.org/10.1016/j.cplett.2011.11.029

no abstracts in English

Conceptual design study of JSFR, 2; Reactor system

Eto, Masao*; Kamishima, Yoshio*; Okamura, Shigeki*; Watanabe, Osamu*; Oyama, Kazuhiro*; Negishi, Kazuo; Kotake, Shoji*; Sakamoto, Yoshihiko; Kamide, Hideki

Proceedings of International Conference on Fast Reactors and Related Fuel Cycles (FR 2009) (CD-ROM), 10 Pages, 2012/00

http://www-pub.iaea.org/mtcd/meetings/PDFplus/2009/cn176/cn176_BoeS.pdf

In the JSFR design, the diameter of the Reactor Vessel (RV) shall be minimized and the reactor internal structures shall be simplified for reduction in construction cost. The reduction in the RV diameter is achieved by adopting an advanced refueling system and the hot RV with high temperature wall. The flow velocity in the reactor upper plenum increases because the diameter of the RV is decreased. As the result, the coolant flow field in reactor upper plenum is severe. The optimization of the coolant flow field in the reactor upper plenum was carried out for prevention the cover gas entrainment and the vortex cavitations at the hot leg intake. In addition, structural integrities for seismic loadings and thermal loadings were evaluated because the design seismic loading was highly increased and the vessel wall is directly exposed to the thermal transients of the upper plenum. This paper describes the characteristics and the results of the design study of the reactor system.