Effects of low- and high-LET radiation on the salt chemotaxis learning in

Sakashita, Tetsuya; Suzuki, Michiyo; Hamada, Nobuyuki*; Shimozawa, Yoko; Fukamoto, Kana*; Yokota, Yuichiro; Sora, Sakura*; Kakizaki, Takehiko*; Wada, Seiichi*; Funayama, Tomoo; et al.

Biological Sciences in Space, 26, p.21 - 25, 2012/10

https://doi.org/10.2187/bss.26.21

High linear energy transfer (LET) radiation is important cosmic rays that has neurobiological effects: it is known to induce conditioned taste aversion, and suppress neurogenesis that may underlie cognitive impairment. However, the impact of high-LET radiation on other learning effects remains largely unknown. Here, we focus on kinetics of the radiation response for the salt chemotaxis learning (SCL) behavior in the nameatode, , because the SCL during the learning conditioning was modulated after low-LET -irradiation. Firstly, the SCL ability was examined following high-LET irradiation (C, 18.3 MeV/u, LET = 113 keV/m), revealing its dose-dependent decrease after high- and low-LET exposure. Next, we demonstrate that the SCL at the early phase of the learning conditioning is greatly affected by high- and low-LET irradiation, and interestingly, the magnitude of these effects by high-LET radiation was smaller than that by low-LET one. Moreover, the analysis of mutant showed that the G-protein subunit, GPC-1 is responsible for such early phase response. This study is the first to provide the evidence for the kinetics of changes in SCL after high-LET irradiation of C. .

Distinct response of irradiated normal human fibroblasts and their bystander cells to heavy-ion radiation in confluent cultures

Hamada, Nobuyuki*; Iwakawa, Mayumi*; Imadome, Kaori*; Funayama, Tomoo; Sakashita, Tetsuya; Sora, Sakura*; Ni, M.*; Imai, Takashi*; Kobayashi, Yasuhiko

Journal of Radiation Research, 50(Suppl.A), P. A118, 2009/05

The Small-molecule Bcl-2 inhibitor HA14-1 sensitizes cervical cancer cells, but not normal fibroblasts, to heavy-ion radiation

Hamada, Nobuyuki*; Kataoka, Keiko*; Sora, Sakura*; Hara, Takamitsu*; Omura, Motoko*; Funayama, Tomoo; Sakashita, Tetsuya; Nakano, Takashi*; Kobayashi, Yasuhiko

Radiotherapy and Oncology, 89(2), p.227 - 230, 2008/11

https://doi.org/10.1016/j.radonc.2008.08.006

Heavy-ion microbeam irradiation induces bystander killing of human cells

Hamada, Nobuyuki*; Hara, Takamitsu*; Omura, Motoko*; Ni, M.*; Funayama, Tomoo; Sakashita, Tetsuya; Sora, Sakura*; Nakano, Takashi*; Kobayashi, Yasuhiko

Uchu Seibutsu Kagaku, 22(2), p.46 - 53, 2008/10

https://doi.org/10.2187/bss.22.46

The Survival of heavy ion-irradiated Bcl-2 overexpressing radioresistant tumor cells and their progeny

Hamada, Nobuyuki*; Hara, Takamitsu*; Omura, Motoko*; Funayama, Tomoo; Sakashita, Tetsuya; Sora, Sakura*; Nakano, Takashi*; Kobayashi, Yasuhiko

Cancer Letters, 268(1), p.76 - 81, 2008/09

https://doi.org/10.1016/j.canlet.2008.03.029

Heavy-ion irradiation overcomes the radioresistance of tumor cells overexpressing Bcl-2

Hamada, Nobuyuki*; Hara, Takamitsu*; Funayama, Tomoo; Sakashita, Tetsuya; Kataoka, Keiko*; Sora, Sakura; Suzuki, Michiyo; Fukamoto, Kana; Yokota, Yuichiro; Omura, Motoko*; et al.

no journal, , 

no abstracts in English

Heavy ion-induced differentiation of normal human fibroblasts

Sora, Sakura; Hamada, Nobuyuki*; Kobayashi, Yasuhiko

no journal, , 

no abstracts in English

Effects of -ray irradiation on the basal slowing response in

Suzuki, Michiyo; Sakashita, Tetsuya; Funayama, Tomoo; Fukamoto, Kana; Hamada, Nobuyuki*; Yokota, Yuichiro; Kataoka, Keiko*; Sora, Sakura; Tsuji, Toshio*; Kobayashi, Yasuhiko

no journal, , 

no abstracts in English

Heavy ion-induced differentiation of normal human fibroblasts

Sora, Sakura; Hamada, Nobuyuki*; Funayama, Tomoo; Sakashita, Tetsuya; Kobayashi, Yasuhiko

no journal, , 

no abstracts in English

HA14-1, an inhibitor of Bcl-2, may sensitize tumor cells to heavy ions

Kataoka, Keiko*; Hamada, Nobuyuki*; Sora, Sakura; Kobayashi, Yasuhiko; Sakashita, Tetsuya; Funayama, Tomoo

no journal, , 

no abstracts in English