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resolutionShimizu, Noriko*; Sugiyama, Shigeru*; Maruyama, Mihoko*; Takahashi, Yoshinori*; Adachi, Motoyasu; Tamada, Taro; Hidaka, Koshi*; Hayashi, Yoshio*; Kimura, Toru*; Kiso, Yoshiaki*; et al.
Crystal Growth & Design, 10(7), p.2990 - 2994, 2010/06
Times Cited Count：11 Percentile：72.02(Chemistry, Multidisciplinary)We report crystal growth of human immunodeficiency virus 1 protease (HIV PR) in a complex with its inhibitor KNI-272 by six different methods. Comparative analysis indicates that top-seeded solution growth (TSSG) and TSSG combined with the floating and stirring technique (TSSG-FAST) are efficient strategies for rapidly obtaining large single crystals and effectively preventing polycrystallization of the seed crystal. Neutron diffraction analysis confirmed that the crystalobtained by TSSG is a high-quality single crystal. Furthermore, crystal shape was observed to be influenced by solution flow, suggesting that the degree of supersaturation significantly affects the crystal growth direction of HIV PR complex. This finding implies that the shape of the HIV PR complex crystal might be controlled by the solution flow rate.
Ikeda, Shugo; Tokiwa, Yoshifumi*; Haga, Yoshinori; Yamamoto, Etsuji; Okubo, Tomoyuki*; Yamada, Mineko*; Nakamura, Noriko*; Sugiyama, Kiyohiro*; Kindo, Koichi*; Inada, Yoshihiko*; et al.
Journal of the Physical Society of Japan, 72(3), p.576 - 581, 2003/03
Times Cited Count：41 Percentile：82.49(Physics, Multidisciplinary)no abstracts in English
SiMatsuda, Tatsuma; Metoki, Naoto; Haga, Yoshinori; Ikeda, Shugo; Okubo, Tomoyuki*; Sugiyama, Kiyohiro*; Nakamura, Noriko*; Kindo, Koichi*; Kaneko, Koji; Nakamura, Akio; et al.
Journal of the Physical Society of Japan, 72(1), p.122 - 130, 2003/01
Times Cited Count：11 Percentile：57.14(Physics, Multidisciplinary)no abstracts in English
Seki, Akiyuki; Suzuki, Kenta*; Akazaki, Tomohiko*; Tamori, Kiyomi; Kitamura, Tomoko; Sugiyama, Noriko; Saito, Kimiaki; Takemiya, Hiroshi
no journal, ,
There has been a growing demand for knowing time series changes in air dose rate and concentration of radioactive materials. Also, from the beginning of the accident, there were a lot of requests for local monitoring information specialized in the area where individuals live or want to know. To respond to those requests, we had improved and developed the information systems using software platform for environmental monitoring data which developed already. Several visualization information that made time series changes easier to understand were added to the Environmental Monitoring Database. Also, we had developed the Environmental Monitoring Infographics which statistically analyzes a large amount of environmental monitoring data and visualizes the change of air dose rate and concentration of radioactive materials. Moreover, we developed the Mapping Tool that can map and graph local environmental monitoring information.
