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Journal Articles

4-Methylumbelliferone administration enhances radiosensitivity of human fibrosarcoma by intercellular communication

Saga, Ryo*; Matsuya, Yusuke; Takahashi, Rei*; Hasegawa, Kazuki*; Date, Hiroyuki*; Hosokawa, Yoichiro*

Scientific Reports (Internet), 11(1), p.8258_1 - 8258_10, 2021/04

 Times Cited Count:4 Percentile:47.6(Multidisciplinary Sciences)

Hyaluronan synthesis inhibitor 4-methylumbelliferone (4-MU) is a candidate of radiosensitizers in X-ray therapy. The curative effects under such 4-MU administration have been investigated in vitro; however, the radiosensitizing mechanisms remain unclear. Here, we investigated the radiosensitizing effects under 4-MU treatment from cell experiments and model estimations. We generated experimental surviving fractions of human fibrosarcoma cells (HT1080) after 4-MU treatment combined with X-ray irradiation. Meanwhilst, we also modelled the pharmacological effects of 4-MU treatment and theoretically analyzed the synergetic effects between 4-MU treatment and X-ray irradiation. The results show that the enhancement of cell killing by 4-MU treatment is the greatest in the intermediate dose range of around 4 Gy, which indicates the involvement of intercellular communication. In addition, the oxidative stress level, which leads to DNA damage induction, significantly increased under 4-MU treatment, and the radiosensitization by 4-MU can be suppressed by the inhibitors for intercellular communication. These findings suggest that the synergetic effects between 4-MU treatment and irradiation are predominantly attributed to intercellular communication and provide more efficient tumour control than conventional X-ray therapy.

Journal Articles

$$omega N$$ scattering length from $$omega$$ photoproduction on the proton near the reaction threshold

Ishikawa, Takatsugu*; Fujimura, Hisako*; Fukasawa, Hiroshi*; Hashimoto, Ryo*; He, Q.*; Honda, Yuki*; Hosaka, Atsushi; Iwata, Takahiro*; Kaida, Shun*; Kasagi, Jirota*; et al.

Physical Review C, 101(5), p.052201_1 - 052201_6, 2020/05

 Times Cited Count:4 Percentile:45.12(Physics, Nuclear)

Journal Articles

Analysis of the high-dose-range radioresistance of prostate cancer cells, including cancer stem cells, based on a stochastic model

Saga, Ryo*; Matsuya, Yusuke; Takahashi, Rei*; Hasegawa, Kazuki*; Date, Hiroyuki*; Hosokawa, Yoichiro*

Journal of Radiation Research, 60(3), p.298 - 307, 2019/05

 Times Cited Count:23 Percentile:81.57(Biology)

In radiotherapy, it is recognized that cancer stem cells (CSCs) in tumor tissue shows radio-resistance. However, the relationship between content percentage of the CSCs and dose-response curve on cell survival remain unclear. In this study, we developed a stochastic model considering progeny cells and stem cells, and investigated the impact of stem cells on radio-sensitivity. From the flow-cytometric analysis (cell experiments), the content percentage of stem cells was 3.2% or less which agreed well with the model estimation from the cell survival curve. Based on the verification, it is suggested that cell survival in high-dose range is largely affected by the CSCs. In addition, regarding the sub-population of stem cells, the present model well reproduces the dose response on lethal lesions to DNA comparing with the conventional LQ model. This outcome indicates that the stem cells must be considered for describing the dose-response curve in wide dose range.

Journal Articles

Study on use of superconducting magnet and first inelastic neutron scattering experiment under magnetic field at 4SEASONS spectrometer

Kajimoto, Ryoichi; Ishikado, Motoyuki*; Kira, Hiroshi*; Kaneko, Koji; Nakamura, Mitsutaka; Kamazawa, Kazuya*; Inamura, Yasuhiro; Ikeuchi, Kazuhiko*; Iida, Kazuki*; Murai, Naoki; et al.

Physica B; Condensed Matter, 556, p.26 - 30, 2019/03

BB2018-0570.pdf:2.17MB

 Times Cited Count:2 Percentile:10.61(Physics, Condensed Matter)

Journal Articles

Status report of the chopper spectrometer 4SEASONS

Kajimoto, Ryoichi; Nakamura, Mitsutaka; Inamura, Yasuhiro; Kamazawa, Kazuya*; Ikeuchi, Kazuhiko*; Iida, Kazuki*; Ishikado, Motoyuki*; Murai, Naoki; Kira, Hiroshi*; Nakatani, Takeshi; et al.

Journal of Physics; Conference Series, 1021(1), p.012030_1 - 012030_6, 2018/06

BB2016-1727.pdf:0.39MB

 Times Cited Count:3 Percentile:88.67(Nuclear Science & Technology)

Journal Articles

Bithiophene with winding vine-shaped molecular asymmetry; Preparation, structural characterization, and enantioselective synthesis

Toyomori, Yuka*; Tsuji, Satoru*; Mitsuda, Shinobu*; Okayama, Yoichi*; Ashida, Shiomi*; Mori, Atsunori*; Kobayashi, Toru; Miyazaki, Yuji; Yaita, Tsuyoshi; Arae, Sachie*; et al.

Bulletin of the Chemical Society of Japan, 89(12), p.1480 - 1486, 2016/09

 Times Cited Count:8 Percentile:29.47(Chemistry, Multidisciplinary)

Journal Articles

2016 Professional Engineer (PE) test preparation course "Nuclear and Radiation Technical Disciplines"

Takahashi, Naoki; Yoshinaka, Kazuyuki; Harada, Akio; Yamanaka, Atsushi; Ueno, Takashi; Kurihara, Ryoichi; Suzuki, Soju; Takamatsu, Misao; Maeda, Shigetaka; Iseki, Atsushi; et al.

Nihon Genshiryoku Gakkai Homu Peji (Internet), 64 Pages, 2016/00

no abstracts in English

Journal Articles

Beam-transport optimization for cold-neutron spectrometer

Nakajima, Kenji; Kawamura, Seiko; Kikuchi, Tatsuya; Kajimoto, Ryoichi; Takahashi, Nobuaki*; Nakamura, Mitsutaka; Soyama, Kazuhiko; Osakabe, Toyotaka

EPJ Web of Conferences, 83, p.03011_1 - 03011_5, 2015/01

 Times Cited Count:3 Percentile:72.17(Physics, Multidisciplinary)

We report the design of the beam-transport system (especially the vertical geometry) for a cold-neutron disk-chopper spectrometer AMATERAS at J-PARC. Based on the elliptical shape, which is one of the most effective geometries for a ballistic mirror, the design was optimized to obtain, at the sample position, a neutron beam with high flux without serious degrading in divergence and spacial homogeneity within the boundary conditions required from actual spectrometer construction. The optimum focal point was examined. An ideal elliptical shape was modified to reduce its height without serious loss of transmission. The final result was adapted to the construction requirements of AMATERAS. Although the ideas studied in this paper are considered for the AMATERAS case, they can be useful also to other spectrometers in similar situations.

Journal Articles

Prognostic significance of amino-acid transporter expression (LAT1, ASCT2, and xCT) in surgically resected tongue cancer

Toyoda, Minoru*; Kaira, Kyoichi*; Ohshima, Yasuhiro; Ishioka, Noriko; Shino, Masato*; Sakakura, Koichi*; Takayasu, Yukihiro*; Takahashi, Katsumasa*; Tominaga, Hideyuki*; Oriuchi, Noboru*; et al.

British Journal of Cancer, 110(10), p.2506 - 2513, 2014/05

 Times Cited Count:106 Percentile:95.14(Oncology)

Journal Articles

Development of multi-purpose MW gyrotrons for fusion devices

Minami, Ryutaro*; Kariya, Tsuyoshi*; Imai, Tsuyoshi*; Numakura, Tomoharu*; Endo, Yoichi*; Nakabayashi, Hidetaka*; Eguchi, Taku*; Shimozuma, Takashi*; Kubo, Shin*; Yoshimura, Yasuo*; et al.

Nuclear Fusion, 53(6), p.063003_1 - 063003_7, 2013/06

Journal Articles

Development of multi-purpose MW gyrotrons for fusion devices

Minami, Ryutaro*; Kariya, Tsuyoshi*; Imai, Tsuyoshi*; Numakura, Tomoharu*; Endo, Yoichi*; Nakabayashi, Hidetaka*; Eguchi, Taku*; Shimozuma, Takashi*; Kubo, Shin*; Yoshimura, Yasuo*; et al.

Nuclear Fusion, 53(6), p.063003_1 - 063003_7, 2013/06

 Times Cited Count:12 Percentile:47.42(Physics, Fluids & Plasmas)

Journal Articles

Recent developments of instruments in a spallation neutron source at J-PARC and those prospects in the future

Arai, Masatoshi; Kajimoto, Ryoichi; Nakamura, Mitsutaka; Inamura, Yasuhiro; Nakajima, Kenji; Shibata, Kaoru; Takahashi, Nobuaki; Suzuki, Junichi*; Takata, Shinichi; Yamada, Takeshi*; et al.

Journal of the Physical Society of Japan, 82(Suppl.A), p.SA024_1 - SA024_14, 2013/01

 Times Cited Count:7 Percentile:47.49(Physics, Multidisciplinary)

The paper describes developments of neutron scattering instruments in J-PARC neutron facility, which is a short pulse spallation source operated at a repetition rate 25 Hz and has a proton power 1 MW. New concept has been adopted to utilize high intensity coupled moderator even for a high resolution inelastic scattering instruments by taking a pulse shaping chopper system. Advanced technique has been also realized by taking an ability of event-recording system altogether with an improvement of a chopper system, realizing multi-Ei method. The paper also touches upon a general design concept for diffractometers in accordance with the source characteristics.

Journal Articles

Emergent phenomena in perovskite-type manganites

Taguchi, Yasujiro*; Sakai, Hideaki*; Okuyama, Daisuke*; Ishiwata, Shintaro*; Fujioka, Jun*; Fukuda, Tatsuo; Hashizume, Daisuke*; Kagawa, Fumitaka*; Takahashi, Yoichiro*; Shimano, Ryo*; et al.

Physica B; Condensed Matter, 407(11), p.1685 - 1688, 2012/06

 Times Cited Count:5 Percentile:23.98(Physics, Condensed Matter)

Journal Articles

Behavior of environmental tritium at NIFS Toki Site of Japan

Sugihara, Shinji*; Tanaka, Masahiro*; Tamari, Toshiya*; Shimada, Jun*; Takahashi, Tomoyuki*; Momoshima, Noriyuki*; Fukutani, Satoshi*; Atarashi-Andoh, Mariko; Sakuma, Yoichi*; Yokoyama, Sumi*; et al.

Fusion Science and Technology, 60(4), p.1300 - 1303, 2011/11

 Times Cited Count:2 Percentile:18.29(Nuclear Science & Technology)

The purpose of this study is to develop the technique to evaluate the environmental tritium behavior of the nuclear facility origin. Tritium concentrations of river water, precipitation and ground water around the NIFS site were determined by low background liquid scintillation measurement system combined with the electrolysis using solid polymer electrolyte. The electric conductivity and flow rate of the river and isotopic ratio of oxygen and hydrogen of water samples were also measured. The tritium concentrations in precipitation showed the seasonal variation and the range were 0.09-0.78 Bq/L. The tritium concentrations of river water and ground water were almost constant, 0.34 and 0.24 Bq/L respectively. The simple dynamic model for the site around the NIFS facilities was developed using measured data, and the behavior of tritium was simulated.

Journal Articles

AMATERAS; A Cold-neutron disk chopper spectrometer

Nakajima, Kenji; Kawamura, Seiko; Kikuchi, Tatsuya; Nakamura, Mitsutaka; Kajimoto, Ryoichi; Inamura, Yasuhiro; Takahashi, Nobuaki; Aizawa, Kazuya; Suzuya, Kentaro; Shibata, Kaoru; et al.

Journal of the Physical Society of Japan, 80(Suppl.B), p.SB028_1 - SB028_6, 2011/05

 Times Cited Count:125 Percentile:95.7(Physics, Multidisciplinary)

AMATERAS is a cold-neutron disk-chopper spectrometer in MLF, J-PARC. The construction of main part of the spectrometer has been completed in spring of 2009. Soon after that, we have started the commissioning work on AMATERAS. The performance of AMATERAS has been examined by test experiments in the course of commissioning. In parallel to these works, we have started the user program on AMATERAS from December 2009 and we are getting scientific results from our spectrometer. In this presentation, we will report the current status of AMATERAS including the results of performance tests and some of examples of scientific outputs.

Journal Articles

Abundances of rare earth elements in crude oils and their partitions in water

Nakada, Ryoichi*; Takahashi, Yoshio*; Zheng, G.*; Yamamoto, Yuhei; Shimizu, Hiroshi*

Geochemical Journal, 44(5), p.411 - 418, 2010/10

 Times Cited Count:27 Percentile:58.17(Geochemistry & Geophysics)

Patterns of the entire range of REE in crude oils and coexisting water, collected from mud volcanoes in Xinjiang Province of China, are reported here for the first time. Crude oils show light REE enriched patterns with flat or depleted patterns in heavy REE, when normalized to chondrite. The REE concentrations in crude oils are larger than those in coexisting water by a factor of more than one hundred. Considering the hydrophobicity of oil and the high ionic characteristics of REE, it is strongly suggested that REE form complexes with ligands present in the crude oils. Based on the $$^{13}$$C NMR spectroscopy, it is found that small amounts of phenol and carboxyl groups are contained in the crude oil samples, which could possibly provide complexing sites for REE. REE patterns of crude oils are similar to those of coexisting mud samples collected from the same mud volcanoes, which suggests that the REE in crude oils are derived from rocks and sediments where crude oils were generated.

Journal Articles

Recent progress in the energy recovery linac project in Japan

Sakanaka, Shogo*; Akemoto, Mitsuo*; Aoto, Tomohiro*; Arakawa, Dai*; Asaoka, Seiji*; Enomoto, Atsushi*; Fukuda, Shigeki*; Furukawa, Kazuro*; Furuya, Takaaki*; Haga, Kaiichi*; et al.

Proceedings of 1st International Particle Accelerator Conference (IPAC '10) (Internet), p.2338 - 2340, 2010/05

Future synchrotron light source using a 5-GeV energy recovery linac (ERL) is under proposal by our Japanese collaboration team, and we are conducting R&D efforts for that. We are developing high-brightness DC photocathode guns, two types of cryomodules for both injector and main superconducting (SC) linacs, and 1.3 GHz high CW-power RF sources. We are also constructing the Compact ERL (cERL) for demonstrating the recirculation of low-emittance, high-current beams using above-mentioned critical technologies.

JAEA Reports

Plan and reports of coupled irradiation (JRR-3 and JOYO of research reactors) and hot facilities work (WASTEF, JMTR-HL, MMF and FMF); R&D project on irradiation damage management technology for structural materials of long-life nuclear plant

Matsui, Yoshinori; Takahashi, Hiroyuki; Yamamoto, Masaya; Nakata, Masahito; Yoshitake, Tsunemitsu; Abe, Kazuyuki; Yoshikawa, Katsunori; Iwamatsu, Shigemi; Ishikawa, Kazuyoshi; Kikuchi, Taiji; et al.

JAEA-Technology 2009-072, 144 Pages, 2010/03

JAEA-Technology-2009-072.pdf:45.01MB

"R&D Project on Irradiation Damage Management Technology for Structural Materials of Long-life Nuclear Plant" was carried out from FY2006 in a fund of a trust enterprise of the Ministry of Education, Culture, Sports, Science and Technology. The coupled irradiations or single irradiation by JOYO fast reactor and JRR-3 thermal reactor were performed for about two years. The irradiation specimens are very important materials to establish of "Evaluation of Irradiation Damage Indicator" in this research. For the acquisition of the examination specimens irradiated by the JOYO and JRR-3, we summarized about the overall plan, the work process and the results for the study to utilize these reactors and some facilities of hot laboratory (WASTEF, JMTR-HL, MMF and FMF) of the Oarai Research-and-Development Center and the Nuclear Science Research Institute in the Japan Atomic Energy Agency.

Journal Articles

Pulse radiolysis study of ion-species effects on the solvated electron in alkylammonium ionic liquids

Kondo, Takafumi*; Asano, Akira*; Yang, J.*; Norizawa, Kimihiro*; Takahashi, Kenji*; Taguchi, Mitsumasa; Nagaishi, Ryuji; Kato, Ryuji*; Yoshida, Yoichi*

Radiation Physics and Chemistry, 78(12), p.1157 - 1160, 2009/12

 Times Cited Count:28 Percentile:85.84(Chemistry, Physical)

Spectrum and kinetic behavior of solvated electrons (e$$_{sol}$$$$^{-}$$) in alkyl ammonium ionic liquids (ILs), ${it i.e.}$ DEMMA-TFSI, DEMMA-BF4, TMPA-TFSI, PP13-TFSI, P13-TFSI and P14-TFSI were investigated by pulse radiolysis method. The e$$_{sol}$$$$^{-}$$ in the ILs have same absorption peak at 1100 nm with a molar absorption coefficient of 1.5-2.3$$times$$10$$^{4}$$ dm$$^{3}$$mol$$^{-1}$$cm$$^{-1}$$. The reaction rate constant of e$$_{sol}$$$$^{-}$$ with Pyrene (Py) was 1.5-3.5$$times$$10$$^{8}$$ dm$$^{3}$$mol$$^{-1}$$s$$^{-1}$$. These values were about one order of magnitude higher than that of diffusion controlled limit, which was calculated from measured viscosity. The dry electron (e$$_{dry}$$$$^{-}$$) reacts with Py, and its rate constant in DEMMA-TFSI was 7.9$$times$$10$$^{11}$$ dm$$^{3}$$mol$$^{-1}$$s$$^{-1}$$, three orders of magnitude higher than that of the e$$_{sol}$$$$^{-}$$ reactions.

JAEA Reports

Development of waste management system, 1; Concept construction of the system

Kuroki, Ryoichiro; Ito, Fuminori*; Nakata, Hisakazu; Yamamoto, Shuji; Takahashi, Kuniaki

JAEA-Technology 2009-016, 124 Pages, 2009/06

JAEA-Technology-2009-016.pdf:3.8MB

The concept of "Waste Management System" which manages all the waste data from generation to disposal in Japan Atomic Energy Agency (JAEA) was studied. At first, development policy was defined on investigation results of the present state and problem of waste management in JAEA, and target information supplied by "Waste Management System" were extracted. Then over 400 data items to be managed in this system, system configuration and specific functions were shown as system concept. The waste data managed on this system are classified into two categories; for quality assurance of waste packages and for optimization study of waste conditioning and disposal and information service. This system consists of analytical part (i.e. program) and management part (i.e. database) for each data, then all these parts are constructed on network.

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