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Fukui, Roman*; Saga, Ryo*; Matsuya, Yusuke; Tomita, Kazuo*; Kuwahara, Yoshikazu*; Ouchi, Kentaro*; Sato, Tomoaki*; Okumura, Kazuhiko*; Date, Hiroyuki*; Fukumoto, Manabu*; et al.
Scientific Reports (Internet), 12(1), p.1056_1 - 1056_12, 2022/01
Times Cited Count：10 Percentile：91.34(Multidisciplinary Sciences)Alive cancer cells after fractionated irradiations with 2 Gy X-rays per day for more than 30 days show clinically relevant radioresistant. Such radioresistance is experimentally interpreted to attributed to the increment of stem-like cell content. However, only an experimental approach cannot clarify the cell responses (DNA damage and cell death induction) of cancer stem cells, so the radioresistant mechanisms remain uncertain. In addition to the conventional cell experiments using radio-resistant cell lines established after fractionated irradiations, in this study we developed a mathematical model (so called integrated microdosimetric-kinetic (IMK) model) explicitly considering cancer stem-like cell content and DNA damage responses and investigated radioresistant mechanisms acquired after fractionated irradiations. The IMK model analysis suggested that the changes of stem-like cell fraction and DNA repair efficiency play important roles of radioresisitance acquired after irradiations. Considering these into the IMK model, we successfully reproduced the experimental survival of various cell lines and various irradiation conditions. This work would contribute to not only the precise understanding of the radioresistant mechanisms induced after irradiation but also predicting curative effects with high precision.
Suzuki, Shintaro*; Takubo, Ko*; Kuga, Kentaro*; Higemoto, Wataru; Ito, Takashi; Tomita, Takahiro*; Shimura, Yasumichi*; Matsumoto, Yosuke*; Bareille, C.*; Wadachi, Hiroki*; et al.
Physical Review Research (Internet), 3(2), p.023140_1 - 023140_12, 2021/05
We report our experimental discovery of the transition temperature reaching 20 K in a Yb-based compound at ambient pressure. The Mn substitution at the Al site in an intermediate valence state of 
-YbAlB
not only induces antiferromagnetic transition at a record high temperature of 20 K but also transforms the heavy-fermion liquid state in -YbAlB into a highly resistive metallic state proximate to a Kondo insulator.
Yoshida, Kensuke*; Fujioka, Shinsuke*; Higashiguchi, Takeshi*; Ugomori, Teruyuki*; Tanaka, Nozomi*; Kawasaki, Masato*; Suzuki, Yuhei*; Suzuki, Chihiro*; Tomita, Kentaro*; Hirose, Ryoichi*; et al.
Applied Physics Letters, 106(12), p.121109_1 - 121109_5, 2015/03
Times Cited Count：10 Percentile：38.07(Physics, Applied)Yoshida, Kensuke*; Fujioka, Shinsuke*; Higashiguchi, Takeshi*; Ugomori, Teruyuki*; Tanaka, Nozomi*; Ohashi, Hayato*; Kawasaki, Masato*; Suzuki, Yuhei*; Suzuki, Chihiro*; Tomita, Kentaro*; et al.
Applied Physics Express, 7(8), p.086202_1 - 086202_4, 2014/08
Times Cited Count：29 Percentile：73.72(Physics, Applied)We demonstrate high conversion efficiency for extreme ultraviolet (EUV) emission at 6.5-6.7 nm from multiple laser beam-produced one-dimensional spherical plasmas. Multiply charged-state ions produce strong resonance emission lines, which combine to yield intense unresolved transition arrays in Gd, Tb, and Mo. The maximum in-band EUV conversion efficiency was observed to be 0.8%, which is one of the highest values ever reported due to the reduction of plasma expansion loss.
Sakai, Yosuke*; Minato, Haruna*; Ishihara, Kohei*; Tomita, Hideki*; Kawarabayashi, Jun*; Iguchi, Tetsuo*; Naka, Tatsuhiro*; Asada, Takashi*; Morishima, Kunihiro*; Nakano, Toshiyuki*; et al.
no journal, ,
In order to measure a neutron-spectrum under high 
ray environment, a new nuclear emulsion and its data-processing method are developed. In fast neutron measurement using the nuclear emulsion which can record the three-dimensional track of a charged particle, incidence neutron energy spectrum can be obtained by analyzing the track of the recoil proton generated by the elastic scattering of a neutron. The high-speed automatic analytic method of the recoil proton track in a nuclear plate is developed. It checked that the recoil proton track length distribution obtained by viewing and automatic analysis was in agreement with a model calculation result about by the basic experiment using 14 MeV neutron.
Sakai, Yosuke*; Minato, Haruna*; Ishihara, Kohei*; Tomita, Hideki*; Kawarabayashi, Jun*; Iguchi, Tetsuo*; Naka, Tatsuhiro*; Asada, Takashi*; Morishima, Kunihiro*; Nakano, Toshiyuki*; et al.
no journal, ,
In order to measure a neutron-spectrum under high ray environment, a new nuclear emulsion and its data-processing method are developed. In fast neutron measurement using the nuclear emulsion which can record the three-dimensional track of a charged particle, incidence neutron energy spectrum can be obtained by analyzing the track of the recoil proton generated by the elastic scattering of a neutron. The high-speed automatic analytic method of the recoil proton track in a nuclear plate is developed. It checked that the recoil proton track length distribution obtained by viewing and automatic analysis was in agreement with a model calculation result about by the basic experiment using 14 MeV neutron.
