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Oral presentation

Refurbishment and restart of JMTR, 10; Technology development for attractive irradiation tests, 4; Extraction of $$^{99m}$$Tc from $$^{99}$$Mo produced by (n,$$gamma$$) method

Kimura, Akihiro; Hori, Naohiko; Tsuchiya, Kunihiko; Ishihara, Masahiro; Tanase, Masakazu*; Yamabayashi, Hisamichi*; Fujisaki, Saburo*; Sato, Yuichi*

no journal, , 

JP, 2009-264740   Patent publication (In Japanese)

To expand industrial utilization of JMTR to be reconstructed, JAEA has a plan to produce $$^{99}$$Mo (half life 65.9h), a parent nuclide of $$^{99m}$$Tc (half life 6.01h) which is used widely as radiopharmaceuticals. There are two methods for $$^{99}$$Mo production; the one is based on nuclear fission of $$^{235}$$U, and the other on neutron irradiation of natural Mo compounds. JAEA has proposed the latter method. On the other hand, the latter method also has some drawbacks that the specific activity of $$^{99}$$Mo and the concentration of $$^{99m}$$Tc in the product solution are very low. And so, to enhance the concentration of the $$^{99m}$$Tc, a method involving a process that the $$^{99m}$$Tc is extracted in methyl ethyl ketone (MEK) has proposed. In this paper, a fundamental study by using Re instead of $$^{99m}$$Tc is presented. Result, developed device can increase the concentration of $$^{99m}$$Tc solution by 20 times.

Patent

高純度99MTC濃縮方法及び濃縮装置

木村 明博; 土谷 邦彦; 石原 正博

山林 尚道*; 棚瀬 正和*; 佐藤 裕一*

JP, 2009-264740  Patent licensing information  Patent publication (In Japanese)

【課題】がん、心筋梗塞、脳卒中をはじめとする疾病の画像診断に必要な高い放射能溶液濃度を持つ99MTcを、短い時間で高純度に製造する方法を提供すること。 【解決手段】純水の溶離液を用いて、ジェネレータ100の高分子ジルコニウム化合物(PZC)から99MTcを溶離させ、得られた99mTc溶離液にケトン系有機溶剤を混合し、99mTc溶離液中の99MTcをケトン系有機溶剤で選択的に抽出し、その後加熱によりケトン系有機溶剤を除去し、高純度かつ高濃度の99MTcを得る。

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