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Project 6 Meeting Members for Tsukuba International Strategic Zone
JAEA-Review 2021-016, 102 Pages, 2021/11
In December 2011, the Prime Minister designated Tsukuba and some areas in Ibaraki Prefecture as "Comprehensive Special Zones". In the Tsukuba International Strategic Zone, nine advanced research and development (R&D) projects are underway with the goal of promoting industrialization of life innovation and green innovation utilizing the science and technology in Tsukuba. In these projects, the domestic production of medical radioisotope (Technetium-99m, Tc) was certified as a new project in October 2013, and R&D have been performed in collaboration with related organizations with Japan Atomic Energy Agency (JAEA) as the project leader. Japan is the third largest consumer of molybdenum-99 (Mo) after the United States and Europe, and all Mo are imported. Supply will be insufficient if overseas reactors are shut down due to trouble or if transportation (air and land transportations) is stopped due to volcanic eruptions and some accidents. Thus, early domestic production of Mo is strongly required. This project is a technology development aimed at domestic production of Mo, which is a raw material of Tc used as a diagnostic agent. This report summarizes the activities carried out in the first and second phase of the domestic production of medical radioisotope (Tc) (here referred to as the "Project 6") in Tsukuba International Strategic Zone (FY2014-2020).
Fujibuchi, Toshio*; Kawamura, Taku*; Yamanashi, Koichi*; Hiroki, Akihiro; Yamashita, Shinichi*; Taguchi, Mitsumasa; Sato, Yuichi*; Mimura, Koichi*; Ushiba, Hiroaki*; Okihara, Toru*
Journal of Physics; Conference Series, 444(1), p.012089_1 - 012089_4, 2013/06
Times Cited Count:3 Percentile:71.63Tanaka, Ichiro*; Kusaka, Katsuhiro*; Hosoya, Takaaki*; Niimura, Nobuo*; Ohara, Takashi*; Kurihara, Kazuo; Yamada, Taro*; Onishi, Yuki*; Tomoyori, Katsuaki*; Yokoyama, Takeshi*
Acta Crystallographica Section D, 66(11), p.1194 - 1197, 2010/11
Times Cited Count:48 Percentile:94.66(Biochemical Research Methods)The IBARAKI Biological Crystal Diffractometer (iBIX), a new diffractometer for protein crystallography at the next-generation neutron source at J-PARC (Japan Proton Accelerator Research Complex), has been constructed and has been operational since December 2008. Preliminary structure analyses of organic crystals showed that iBIX has high performance even at 120 kW operation and the first full data set is being collected from a protein crystal.
Tanaka, Ichiro*; Kusaka, Katsuhiro*; Hosoya, Takaaki*; Ohara, Takashi*; Kurihara, Kazuo; Niimura, Nobuo*
Yakugaku Zasshi, 130(5), p.665 - 670, 2010/05
Times Cited Count:0 Percentile:0.02(Pharmacology & Pharmacy)Ibaraki Prefectural Government together with Ibaraki University and Japan Atomic Energy Agency (JAEA) has almost finished constructing a time-of-flight (TOF) neutron diffractometer for biological macromolecules for industrial use at J-PARC, IBARAKI Biological Crystal Diffractometer (iBIX). Since 2009, Ibaraki University has been asked to operate this machine in order for users to do experiments by Ibaraki Prefecture. The diffractometer is designed to cover sample crystals which have their cell edges up to around 150 . It is expected to measure more than 100 samples per year if they have 2 mm in crystal volume, and to measure even around 0.1 mm in crystal volume of biological samples. The efficiency of iBIX is also expected about 100 times larger than those of the present high performance diffractometers at JRR-3 in JAEA when 1MW power realizes in J-PARC. Since December 2008, iBIX has been open to users and several proteins and organic compounds were tested under 20 kW proton power of J-PARC. It was found that one of their proteins was diffracted up to 1.4 in d-spacing, which was nearly comparable resolution to that of BIX-3 in JRR-3 when used the same crystal as at iBIX for reasonable exposure time. In May 2009, 14 detector units were set up. By the end of fiscal year 2009, the basic part of data reduction software will be finished and an equipment blowing low temperature gas to the sample will be installed with the cooperation of JAEA.
Yamanishi, Takeshi; Seshimo, Kazuyoshi; Kitami, Takayuki; Tan, Sakyo*
Nihon Ryokka Kogakkai-Shi, 32(1), p.191 - 194, 2006/08
no abstracts in English
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JAERI-M 4461, 34 Pages, 1971/06
no abstracts in English
Tanaka, Ichiro*; Ohara, Takashi; Kurihara, Kazuo; Kusaka, Katsuhiro; Ozeki, Tomoji*; Niimura, Nobuo*
no journal, ,
Ibaraki Prefectural Government in Japan has started to construct a neutron diffractometer for biological macromolecules for industrial use at J-PARC. The diffractometer is designed to cover the sample crystals which have their cell edges less than 135 . It is expected to measure 100 samples per year if they have 2mm in crystal volume. The efficiency is more than 50 times larger than the present high performance diffractometers, BIX-3 and BIX-4 in JRR-3 reactor, in JAERI. To realize this performance, three important and key items should be developed; an detector, neutron optics, and a software in data reduction. The current status of these developments will be reported with the latest parameters of this diffractometer.
Kusaka, Katsuhiro; Ohara, Takashi; Tanaka, Ichiro*; Niimura, Nobuo*; Ozeki, Tomoji*; Kurihara, Kazuo; Aizawa, Kazuya; Morii, Yukio; Arai, Masatoshi; Ebata, Kazuhiro*; et al.
no journal, ,
The TOF neutron biological diffractometer in J-PARC proposed by Ibaraki prefectural government is designed to cover the samples have their cell edges up to 135A, and to realize the efficiency is more than 50 times larger than the present high performance diffractometer, BIX-4. To achieve this performance, the diffractometer will be installed on a coupled moderator has more intense peak but wider pulse shape. The overlapping of Bragg spots along the time-axis expected should be considered for the determination of optic parameters and it is necessary to de-convolute the overlapped spots with higher accuracy. The original simulation programs of TOF diffraction data were developed to obtain information of spot-overlapping, completeness of Bragg spots and spot profiles along time-axis. In this paper, the consideration of important designed parameters focused on biological macromolecular and the strategy of de-convoluting overlapped spots will be reported based on the simulation results.
Yamanishi, Takeshi
no journal, ,
no abstracts in English
Ohara, Takashi; Kurihara, Kazuo; Kusaka, Katsuhiro; Hosoya, Takaaki; Tanaka, Ichiro*; Niimura, Nobuo*; Ozeki, Tomoji*; Aizawa, Kazuya; Morii, Yukio; Arai, Masatoshi; et al.
no journal, ,
no abstracts in English
Kusaka, Katsuhiro; Ohara, Takashi; Tanaka, Ichiro*; Niimura, Nobuo*; Kurihara, Kazuo; Hosoya, Takaaki; Ozeki, Tomoji*; Aizawa, Kazuya; Morii, Yukio; Arai, Masatoshi; et al.
no journal, ,
Ibaraki prefecture has started to construct IBARAKI biological crystal diffractometer for industrial use at MLF, J-PARC. It is designed to achieve the efficiency which is more than 50 times larger than the present high performance diffractometer BIX-4. To realize this performance, the diffractometer will be installed on a coupled moderator has more intense peak but wider pulse shape than a decoupled one. It is expected that some neighbor Bragg spots will overlap partially each other along the time axis. The overlapping of Bragg spots should be considered for optimization of design parameters and it is necessary to de-convolute the overlapped spots. The three original simulation programs of TOF diffraction data with designed parameters of the diffractometer were developed to obtain information of spot-overlapping, completeness of Bragg spots and spot profiles along the time axis. The consideration of important designed parameters will be reported based on the simulation results.
Kusaka, Katsuhiro; Ohara, Takashi; Tanaka, Ichiro*; Niimura, Nobuo*; Kurihara, Kazuo; Hosoya, Takaaki; Ozeki, Tomoji*; Aizawa, Kazuya; Morii, Yukio; Arai, Masatoshi; et al.
no journal, ,
no abstracts in English
Ohara, Takashi
no journal, ,
no abstracts in English
Ohara, Takashi; Kurihara, Kazuo; Kusaka, Katsuhiro; Hosoya, Takaaki; Tanaka, Ichiro*; Niimura, Nobuo*; Ozeki, Tomoji*; Aizawa, Kazuya; Morii, Yukio; Arai, Masatoshi; et al.
no journal, ,
Ibaraki Prefectural Government in Japan has started to construct a TOF single crystal neutron diffractometer for biological macromolecules for industrial use at J-PARC. For this diffractometer, design of an efficient neutron transportation system is important because this diffractometer has 40m source-sample distance. Recently, we designed a supermirror neutron guide which can transport 0.7-3.8 Angstrom neutron efficiently. The total length of the mirror section is 25m. At the first 17m, the mirror has curvature (R=4300m) for horizontal direction in order to remove high-energy neutron and ray. Simultaneously, all of the mirror section has tapered angle for vertical direction in order to reduce the frequency of neutron reflection at the surface of the supermirror. The neutron flux and profile at the sample position was calculated by Monte Carlo simulation softwares, McStas and IDEAS and compared with a curved, non-tapered guide we had designed previously. In result, the new supermirror system has 2 times gain for 0.7 Angstrom neutron and 1.5 times for 1.5 Angstrom neutron, and the beam profile at the sample position has a rectangular shape.
Ohara, Takashi
no journal, ,
no abstracts in English
Tanaka, Ichiro*; Ohara, Takashi; Kurihara, Kazuo; Kusaka, Katsuhiro*; Hosoya, Takaaki; Tomoyori, Katsuaki*; Niimura, Nobuo*; Ozeki, Tomoji*; Aizawa, Kazuya; Arai, Masatoshi; et al.
no journal, ,
IBARAKI Biological Crystal Diffractometer is a new single-crystal neutron diffractometer for biological and chemical crystallography, and is now being constructed at J-PARC by Ibaraki Prefectural Government in Japan. This diffractometer is designed for the protein crystals with the cell dimension up to 135 . The measurement efficiency is more than 50 times larger than the present neutron diffractometer, BIX-3/BIX-4 in JRR-3 reactor at JAEA. To achieve this performance, we have selected a coupled moderator, and worked out the optimisation of the neutron guide tube. For the detector, a new wavelength-shifting-fiber type scintillation area detector system with high spatial (0.5-1.0 mm) and time (1ms-) resolution are in development.
Ohara, Takashi; Kusaka, Katsuhiro*; Hosoya, Takaaki; Kurihara, Kazuo; Tomoyori, Katsuaki*; Niimura, Nobuo*; Tanaka, Ichiro*; Suzuki, Jiro*; Nakatani, Takeshi; Otomo, Toshiya*; et al.
no journal, ,
For a single crystal diffractometer, a data reduction software which extracts a HKLF list from the raw data is one of the most important components. We are now developing a new data reduction software for a new single crystal neutron diffractometer, "IBARAKI Biological Crystal Diffractometer (iBIX)", which is now constructing at the MLF of J-PARC.
Ohara, Takashi; Kusaka, Katsuhiro*; Hosoya, Takaaki*; Kurihara, Kazuo; Tomoyori, Katsuaki*; Niimura, Nobuo*; Tanaka, Ichiro*; Suzuki, Jiro*; Nakatani, Takeshi; Otomo, Toshiya*; et al.
no journal, ,
no abstracts in English
Ohara, Takashi; Kurihara, Kazuo; Nakatani, Takeshi; Suzuki, Jiro*; Otomo, Toshiya*; Hosoya, Takaaki*; Kusaka, Katsuhiro*; Tanaka, Ichiro*; Niimura, Nobuo*; Seki, Akiyuki; et al.
no journal, ,
no abstracts in English
Ohara, Takashi
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no abstracts in English