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Komoto, Kazuki*; Nogawa, Norio*; Sato, Jun*; Makide, Yoshihiro*; Morikawa, Naotake*; Hashimoto, Kazuyuki; Sorita, Takami
no journal, ,
Complex compound of Re and Re with meso-2,3-dimercaptosuccinic acid (DMSA) is expected to be effective against cancerous disease. This compound is synthesized with high radiochemical yield by use of SnCl as reducing reagent. However, the product contains a large amount of SnCl which is harmful to human body. The removal of tin impurity was tested with cation exchange resin. Re-DMSA complex was also obtained with high radiochemical yield by use of other harmless reducing agents (L-ascorbic acid, NaSO, HPO). Synthesized Re-DMSA by use of SnCl was stable in sodium acetate buffer for 5 hours, while survival amount of Re-DMSA synthesized by other reducing agents decreased in a short time.
Nogawa, Norio*; Ikeda, Keishiro*; Morikawa, Naotake*; Motoishi, Shoji; Matsuoka, Hiromitsu; Hashimoto, Kazuyuki
no journal, ,
Rhenium-186(T=90h; E=1.1 MeV; E=137 keV) and rhenium-188(T=17h; E=2.1 MeV; E=153 keV) are particle emitting radionuclides with excellent properties for targeted radiotherapy. Re-188 has the advantages associated with carrier-free, generator-produced radionuclides. PZC generator with many tungsten molecules is expected for as practical generator. This generator was experimented for clarifying a characteristic. Meso-2,3-dimercaptosuccinic acid (DMSA) is applied for palliative treatment of pain associated with disease. Effect of pH is studied on preparation of Re-DMSA.
Ishioka, Noriko
no journal, ,
no abstracts in English