A Combination use of boron and gadolinium compounds in NCT trial

Zhang, T.*; Matsumura, Akira*; Yamamoto, Tetsuya*; Yoshida, Fumiyo*; Sakurai, Yoshinori*; Kumada, Hiroaki; Yamamoto, Kazuyoshi ; Nose, Tadao*

From present study, the irradiation effect by using combination of Boron and Gd, showed various irradiation effects (additive effect, less than additive effect, non additive effect), which depend on Gd concentration. The additive effect will be occurred when using a combination of Gd and Boron with low concentration, however, adding Gd to high concentration will reduce additive effect resulting in less than additive to finally non-additive effect. This result indicate that achieving suitable concentrations of Gd and Boron together in tumors may increase the therapy effect, but achieving excess concentration of Gd with Boron together in tumor may cause negative therapeuitic effect.