Electrostatic energy analysis of 8-oxoguanine DNA lesion; Molecular dynamics study

Pinak, M.

One nanosecond molecular dynamics (MD) simulation was performed for two DNA segments each composed of 30 base pairs. The analysis of results was focused on the electrostatic energy that is supposed to be significant factor causing the disruption of DNA base stacking in DNA duplex and may also to serve as a signal toward the repair enzyme informing on the presence of the lesion. This electrostatic potential may signal presence of the lesion to the repair enzyme.

Language	:	English
Journal	:	Computational Biology and Chemistry
Volume	:	27
Number	:	3
Pages	:	p.431 - 441
Publication Year/Month	:	2003/07
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Paper URL	:	https://doi.org/10.1016/S1476-9271(02)00104-4
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Keywords	:	DNA; 8-oxoguanine; Electrostatic Energy; Flipped-out Base; MD
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Web of Science® Times Cited Count	:	Times Cited Count： If you would like to get the latest times cited, please access the Web of Science®. http://www.webofknowledge.com/wos
InCites™	:	Percentile:45.21 Category:Biology
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Registration No. : A20020546
JAEA Abstracts No. : 320342
Paper Submission No. : 20809

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