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Enhancement of sodium borocaptate (BSH) uptake by tumor cells induced by glutathione depletion and its radiobiological effect

Yoshida, Fumiyo*; Matsumura, Akira*; Yamamoto, Tetsuya*; Kumada, Hiroaki; Nakai, Kei*

Sodium borocaptate (BSH) is widely used for Boron Neutron Capture Therapy (BNCT) of brain tumors. However, the mechanism of uptake by the tumor remains unclear. We investigated the sulfhydryl moiety of this compound. Down regulation of glutathione (GSH) by buthionine sulfoximine (BSO) in cultured cells resulted in increase of BSH uptake (7.9 %-36.5 %) compared to control group and subsequently cytocidal effect of neutron irradiation also increased. The radiation damage by $$gamma$$-ray irradiation was suppressed by enhancement of BSH uptake. These findings suggested that modulation of GSH induce enhancement effect of B(n,$$alpha$$) reaction and protective effect of secondary $$gamma$$-ray in BNCT.

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Category:Oncology

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