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Down-regulation of radioresistance by LexA2 in ${it Deinococcus radiodurans}$

Sato, Katsuya; Oba, Hirofumi; Sghaier, H.; Narumi, Issei

In an effort to gain an insight into the role of LexA2 in the radiation response mechanism, ${it lexA2}$ disruptant strain was generated and investigated. The ${it lexA2}$ disruptant strains exhibited a much higher resistance to $$gamma$$ rays than the wild-type strain. Furthermore, a luciferase assay showed that ${it pprA}$ promoter activation was enhanced in the ${it lexA2}$ disruptant strain following $$gamma$$ irradiation. The increase in radioresistance of the ${it lexA2}$ disruptant strain is explained in part by the enhancement of ${it pprA}$ promoter activation.

Language

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English

Journal

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Microbiology

Volume

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152

Number

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11

Pages

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p.3217 - 3226

Publication Year/Month

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2006/11

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Held date

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Location (country)

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Paper URL

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DOI for research data

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Keywords

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no keyword

Research Facility

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コバルト60照射施設

Press Release

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Article of JAEA R&D Review

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Discovery of Activation Enhancement Mechanism of DNA Repair Promoting Gene pprA; Role of Radiation Response Protein LexA2[/]

Cooperating Institute

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Accesses

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- Accesses

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