Effects of Abasic site and 8oxoG lesions on DNA molecule

Higuchi, Mariko; Pinak, M.; Saito, Kimiaki

The cluster damaged site on DNA consisting of 7,8-dihydro-8-oxoguanine (8oxoG) and apurinic/apyrimidinic (AP) site is one example of damage that inhibits enzymatic repair. The 2 nanosecond molecular dynamics simulation revealed that the effect of AP site was lager than it of 8oxoG in multiple damaged DNA. The multiple damaged DNA was bent mainly at AP site. Bending direction of multiple damaged DNA including AP site and 8oxoG was different from that at the lesion site of single 8oxoG damaged DNA. These changes may have an influence on the effectiveness of enzymatic repair.

Language	:	English
Journal	:	Hoken Butsuri
Volume	:	42
Number	:	2
Pages	:	p.166 - 173
Publication Year/Month	:	2007/06
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Paper URL	:	https://doi.org/10.5453/jhps.42.166
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Keywords	:	no keyword
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Cooperating Institute	:	放射線医学総合研究所

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Registration No. : AA20060978
JAEA Abstracts No. : 35001611
Paper Submission No. : 3191

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