Effects of heavy-ion, UV-C, and X-ray irradiation on the susceptibilities of human cells to HIV-1 infection

ヒト細胞のHIV-1ウイルス感染感受性に対する重イオン,UV-C,X線照射の影響

清水 宣明*; 大上 厚志*; 大槻 貴博*; 森 隆久*; 山口 華代*; 中村 孝子*; 和田 成一*; 小林 泰彦; 星野 洪郎*

Shimizu, Nobuaki*; Oue, Atsushi*; Otsuki, Takahiro*; Mori, Takahisa*; Yamaguchi, Kayo*; Nakamura, Takako*; Wada, Seiichi*; Kobayashi, Yasuhiko; Hoshino, Hiroo*

In this study, we show that heavy ion irradiation at low doses has enhancing effects on the susceptibility of NP-2/CD4/CCR5 cells to HIV-1. This enhancing effect was specifically detected when the cells were irradiated with heavy ion but not with UV-C and X-ray. Enhancement of HIV-1 infection may be accomplished by up-regulation of viral incorporation into the cells or reverse-transcription of the viral genomic RNA. Thus, heavy-ion irradiation will be a useful tool to analyze the mechanism of HIV-1 infection in human cells.