Effects of heavy-ion, UV-C, and X-ray irradiation on the susceptibilities of human cells to HIV-1 infection

Shimizu, Nobuaki*; Oue, Atsushi*; Otsuki, Takahiro*; Mori, Takahisa*; Yamaguchi, Kayo*; Nakamura, Takako*; Wada, Seiichi*; Kobayashi, Yasuhiko; Hoshino, Hiroo*

In this study, we show that heavy ion irradiation at low doses has enhancing effects on the susceptibility of NP-2/CD4/CCR5 cells to HIV-1. This enhancing effect was specifically detected when the cells were irradiated with heavy ion but not with UV-C and X-ray. Enhancement of HIV-1 infection may be accomplished by up-regulation of viral incorporation into the cells or reverse-transcription of the viral genomic RNA. Thus, heavy-ion irradiation will be a useful tool to analyze the mechanism of HIV-1 infection in human cells.

Language	:	English
Journal	:	JAEA-Review 2006-042, JAEA Takasaki Annual Report 2005
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Pages	:	P. 105
Publication Year/Month	:	2007/02
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Paper URL	:	https://jopss.jaea.go.jp/pdfdata/JAEA-Review-2006-042.pdf
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Keywords	:	no keyword
Research Facility	:	TIARA(イオン照射研究施設)
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Cooperating Institute	:	群馬大学

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Registration No. : AA20070040
JAEA Abstracts No. :
Paper Submission No. : 2397

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