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Heavy ion microbeam irradiation to the central nervous system of ${it Caenorhabditis elegans}$ and development of effect prediction simulator; Why is associative learning of ${it Caenorhabditis elegans}$ promoted by ionizing irradiation ?

Sakashita, Tetsuya; Hamada, Nobuyuki*; Suzuki, Michiyo*; Tsuji, Toshio*; Kakizaki, Takehiko; Wada, Seiichi*; Funayama, Tomoo; Kobayashi, Yasuhiko

We investigated the effects of ionizing radiation on the food-NaCl associative learning using ${it Caenorhabditis elegans}$, well known as a model organism for a nervous system. Normally, ${it C. elegans}$ moves towards NaCl, but animals show behavior to avoid NaCl when they have experienced starvation and NaCl simultaneously. This behavior has been termed "associative learning". The results of $$gamma$$-ray irradiation experiments revealed the followings: (1) Radiation responses occurred only in the animals conditioned with starvation and NaCl, (2) The changes consisted of early- and late-phase components. In addition, the preparation of animals for heavy ion microbeam irradiation has been developed for the food-NaCl associative learning of ${it C. elegans}$. Using the preparation, we found that chemotaxis towards NaCl was not affected by the targeted irradiation to the nervous ring of ${it C. elegans}$. Furthermore, the simulation model that reflected a neuron network of food-NaCl associative learning has been developed.

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