線虫の神経中枢への重イオンマイクロビーム照射と効果予測シミュレーターの開発; 放射線照射によりなぜ線虫の連合学習が促進されるのか?

Heavy ion microbeam irradiation to the central nervous system of and development of effect prediction simulator; Why is associative learning of promoted by ionizing irradiation ?

坂下 哲哉; 浜田 信行*; 鈴木 芳代*; 辻 敏夫*; 柿崎 竹彦; 和田 成一*; 舟山 知夫; 小林 泰彦

Sakashita, Tetsuya; Hamada, Nobuyuki*; Suzuki, Michiyo*; Tsuji, Toshio*; Kakizaki, Takehiko; Wada, Seiichi*; Funayama, Tomoo; Kobayashi, Yasuhiko

We investigated the effects of ionizing radiation on the food-NaCl associative learning using , well known as a model organism for a nervous system. Normally, moves towards NaCl, but animals show behavior to avoid NaCl when they have experienced starvation and NaCl simultaneously. This behavior has been termed "associative learning". The results of -ray irradiation experiments revealed the followings: (1) Radiation responses occurred only in the animals conditioned with starvation and NaCl, (2) The changes consisted of early- and late-phase components. In addition, the preparation of animals for heavy ion microbeam irradiation has been developed for the food-NaCl associative learning of . Using the preparation, we found that chemotaxis towards NaCl was not affected by the targeted irradiation to the nervous ring of . Furthermore, the simulation model that reflected a neuron network of food-NaCl associative learning has been developed.