A Study on free radical scavenging properties of edaravone and its derivatives by pulse radiolysis

Hata, Kuniki ; Katsumura, Yosuke; Lin, M.; Muroya, Yusa*; Fu, H.*; Kudo, Hisaaki*; Nakagawa, Keiichi*; Nakagawa, Hidehiko*

To help for a better understanding about the mechanism of oxidation reactions of edaravone, the transient absorption spectrum and reactivity of edaravone towards various oxidative radicals ( $^{.}$ OH, N $_{3}$ $^{.}$ , Br $_{2}$ $^{.-}$ , SO $_{4}$ $^{.-}$ , and CCl $_{3}$ O $_{2}$ $^{.}$ ) are studied by pulse radiolysis techniques. The spectrum of its reaction with $^{.}$ OH is quite different from those with the other oxidizing radicals, because the main transient is of OH-adducts for OH reaction while it is of electron-transfer or H-abstraction for the others. The rate constants of the reaction with $^{.}$ OH, N $_{3}$ $^{.}$ , SO $_{4}$ $^{.-}$ , and CCl $_{3}$ O $_{2}$ $^{.}$ are estimated to be 8.710 $^{9}$ , 5.410 $^{9}$ , 6.010 $^{8}$ , and 5.110 $^{8}$ M $^{-1}$ s $^{-1}$ , respectively. Moreover the rate constants of the reaction of some edaravone derivatives with $^{.}$ OH are estimated.

Language	:	English
Journal	:
Volume	:
Number	:
Pages	:
Publication Year/Month	:
Meeting title	:	International Symposium on Charged Particle and Photon Interactions with Matter (ASR 2007)
Held date	:	2007/11
Location (city)	:	Tokai
Location (country)	:	Japan
Patent information	:
PDF	:
Paper URL	:
DOI for research data	:
Keywords	:	no keyword
Research Facility	:
Press Release	:
Article of JAEA R&D Review	:
Cooperating Institute	:	名古屋市立大学; 東京大学

Accesses	:	- Accesses
Web of Science® Times Cited Count	:	Times Cited Count： If you would like to get the latest times cited, please access the Web of Science®. http://www.webofknowledge.com/wos
InCites™	:
Altmetrics	:

Registration No. : BB20072439
JAEA Abstracts No. :
Paper Submission No. :

[CLARIVATE ANALYTICS], [WEB OF SCIENCE], [HIGHLY CITED PAPER & CUP LOGO] and [HOT PAPER & FIRE LOGO] are trademarks of Clarivate Analytics, and/or its affiliated company or companies, and used herein by permission and/or license.