A Study on the reactivity of Edaravone with oxidative radicals by pulse radiolysis

Hata, Kuniki ; Katsumura, Yosuke; Lin, M.; Muroya, Yusa*; Kudo, Hisaaki*; Nakagawa, Keiichi*; Nakagawa, Hidehiko*

Edaravone, 3-methyl-1-phenyl-2-pyrazolin-5-one, is a newly developed free radical scavenger that has been approved in Japan as a neuroprotective drug since 2001. In the present work, the transient intermediates and the reactivity of edaravone towards $^{.}$ OH, N $_{3}$ $^{.}$ , Br $_{2}$ $^{.-}$ , SO $_{4}$ $^{.-}$ , and CCl $_{3}$ O $_{2}$ $^{.}$ are investigated by pulse radiolysis techniques. The oxidation of edaravone by N $_{3}$ $^{.}$ , Br $_{2}$ $^{.-}$ , SO $_{4}$ $^{.-}$ , and CCl $_{3}$ O $_{2}$ $^{.}$ results in an absorption band with $_{max}$ = 345 nm ( $_{345nm}$ = 2600 M $^{-1}$ cm $^{-1}$ ), which is assigned to the edaravone radical formed by H-abstraction or electron transfer. However, the transient species produced by the reaction of edaravone with $^{.}$ OH radical shows an absorption band with $_{max}$ = 320 nm ( $_{320nm}$ = 4900 M $^{-1}$ cm $^{-1}$ ). Accordingly, the main transient species by the reaction of edaravone with $^{.}$ OH radical in the absence of O $_{2}$ is attributed to OH-adducts. The rate constants of edaravone reacting with $^{.}$ OH, N $_{3}$ $^{.}$ , SO $_{4}$ $^{.-}$ , and CCl $_{3}$ O $_{2}$ $^{.}$ are estimated to be 8.510 $^{9}$ , 5.410 $^{9}$ , 6.010 $^{8}$ , and 5.110 $^{8}$ M $^{-1}$ s $^{-1}$ , respectively.

Language	:	Japanese
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Meeting title	:	日本放射線影響学会第50回大会
Held date	:	2007/11
Location (city)	:	千葉
Location (country)	:	日本
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Keywords	:	no keyword
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Cooperating Institute	:	名古屋市立大学; 東京大学

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Registration No. : BB20072592
JAEA Abstracts No. :
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