Basic study on activation of antioxidation function in some organs of mice by radon inhalation using new radon exposure device

Nakagawa, Shinya*; Kataoka, Takahiro*; Sakoda, Akihiro*   ; Ishimori, Yuu  ; Hanamoto, Katsumi*; Yamaoka, Kiyonori*

There are a lot of life style diseases that are related to reactive oxygen species in inductions of the radon therapy, and the further clarification of mechanism is expected. In this study, we investigated the activation of antioxidation function in some organs of mice by radon inhalation using the new radon exposure device. The mice were made to inhale the radon of 400Bq/m or 4000Bq/m with the device. Results show that in brain, lungs, liver and kidney, both the activities of superoxide dismutase and catalase increased, and lipid peroxide levels decreased. This suggests that radon inhalation enhanced the antioxidation function. These findings are important in understanding the mechanism of diseases in which radon therapy is used as treatment, and most of which are called activated oxygen-related diseases.