ラドン吸入試作装置によるマウス諸臓器中の抗酸化機能の亢進に関する研究

Basic study on activation of antioxidation function in some organs of mice by radon inhalation using new radon exposure device

中川 慎也*; 片岡 隆浩*; 迫田 晃弘*   ; 石森 有  ; 花元 克巳*; 山岡 聖典*

Nakagawa, Shinya*; Kataoka, Takahiro*; Sakoda, Akihiro*; Ishimori, Yuu; Hanamoto, Katsumi*; Yamaoka, Kiyonori*

ラドン療法の適応症には活性酸素に由来する生活習慣病が多く、その機構のさらなる解明が期待されている。開発したラドン吸入試作装置を用いてマウス諸臓器中の抗酸化機能の変化特性を検討した。400Bq/mあるいは4000Bq/mのラドンを吸入させた。その結果、脳,肺,肝臓,腎臓において、抗酸化系酵素であるSODとカタラーゼの両活性が増加し、過酸化脂質が減少した。この抗酸化機能の亢進によって、活性酸素障害の抑制、つまり生活習慣病の予防や症状緩和に効果がある可能性が示唆された。

There are a lot of life style diseases that are related to reactive oxygen species in inductions of the radon therapy, and the further clarification of mechanism is expected. In this study, we investigated the activation of antioxidation function in some organs of mice by radon inhalation using the new radon exposure device. The mice were made to inhale the radon of 400Bq/m or 4000Bq/m with the device. Results show that in brain, lungs, liver and kidney, both the activities of superoxide dismutase and catalase increased, and lipid peroxide levels decreased. This suggests that radon inhalation enhanced the antioxidation function. These findings are important in understanding the mechanism of diseases in which radon therapy is used as treatment, and most of which are called activated oxygen-related diseases.