Production of radioisotopes for nuclear medicine using ion-beam technology and its utilization for both therapeutic and diagnostic application in cancer

Iida, Yasuhiko*; Hanaoka, Hirofumi*; Paudyal, P.*; Paudyal, B.*; Watanabe, Satoshi; Ishioka, Noriko; Watanabe, Shigeki; Matsuhashi, Shimpei; Yoshioka, Hiroki*; Higuchi, Tetsuya*; Oriuchi, Noboru*; Endo, Keigo*

Optical imaging is recently developed for in vivo molecular imaging. It requires only a simple system, and has advantage of relatively low cost. Furthermore, optical imaging probes can provide the highest signal-to-noise ratio for molecular targeting, so optical imaging is ideal candidate for molecular imaging. In this study, we prepared a probe, which labeled with both radioisotope and fluorescent dye, and evaluated the difference of images from PET and optical imaging, and compare the characteristics of both imaging methods. From our results, multimodal imaging system can provide complementary information about the functional status of various tissues, and can improve the accuracy of tumor diagnosis.