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Toyocamycin specifically inhibits auxin signaling mediated by SCF$$^{TIR1}$$ pathway

トヨカマイシンはSCF$$^{TIR1}$$経路のオーキシン情報伝達を阻害する

林 謙一郎*; 神尾 秀一*; 大野 豊; Townsend, L.*; 野崎 浩*

Hayashi, Kenichiro*; Kamio, Shuichi*; Ono, Yutaka; Townsend, L.*; Nozaki, Hiroshi*

Toyocamycin, a nucleoside-type antibiotic, was identified as auxin signaling inhibitor in a screen of microbial extracts for inhibition of the auxin-inducible reporter gene assay. Toyocamycin specifically inhibited auxin-responsive gene expression, but did not affect other hormone-inducible gene expression. Toyocamycin also blocked auxin-enhanced degradation of the Aux/IAA repressor modulated by the SCF$$^{TIR1}$$ ubiquitin-proteasome pathway without inhibiting proteolytic activity of proteasome. Furthermore, toyocamycin inhibited auxin-induced lateral root formation and epinastic growth of cotyledon in the Arabidopsis thaliana plant. This evidence suggested that toyocamycin would act on the ubiquitination process regulated by SCF$$^{TIR1}$$ machineries. To address the structural requirements for the specific activity of toyocamycin on auxin signaling, the structure-activity relationships of nine toyocamycin-related compounds, including sangivamycin and tubercidin, were investigated.

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パーセンタイル:56.68

分野:Biochemistry & Molecular Biology

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