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Report No.

Genetic interaction between ${it AXR1}$ and ${it SMAP1}$ that function in the 2,4-D signal transduction pathway in ${it Arabidopsis}$

Ono, Yutaka; Nakasone, Akari; Uchimiya, Hirofumi*; Narumi, Issei

The ${it Small Acidic Protein 1}$ (${it SMAP1}$) gene is responsible for the anti-auxin resistant mutation, ${it aar1}$, and encodes a factor that mediates the synthetic auxin 2,4-D response. To gain an insight into the function of SMAP1, the ${it aar1}$ mutant was crossed with known auxin-related mutants. The double mutants, ${it aar1-1 tir1-1}$, ${it aar1-1 ecr1-1}$, and ${it aar1-1 aar3-2}$ showed more resistant to 2,4-D than the corresponding single mutants in root growth assay. On the other hand, the ${it axr1 aar1}$ double mutants showed severe morphological defects with a lack of root meristem formation. The overexpression of ${it SMAP1-GFP}$ fusion gene under 35S promoter relieved pleiotropic morphological phenotypes of ${it axr1-12}$ such as dwarf, multiple shoots, altered flower structure, low fertility and reduced auxin response. The results suggested that the function of ${it SMAP1}$ is tightly linked to that of ${it AXR1}$ in genetic level.



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