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Production of no-carrier-added $$^{177}$$Lu for radioimmunotherapy

放射免疫療法のための無担体$$^{177}$$Luの製造法の開発

渡辺 智; 橋本 和幸; 渡邉 茂樹; 飯田 靖彦*; 花岡 宏史*; 遠藤 啓吾*; 石岡 典子

Watanabe, Satoshi; Hashimoto, Kazuyuki; Watanabe, Shigeki; Iida, Yasuhiko*; Hanaoka, Hirofumi*; Endo, Keigo*; Ishioka, Noriko

Lutetium-177 is considered to have potential for application in radioimmunotherapy, because it emits $$beta$$-particles (E$$_{max}$$=498 keV) suitable to penetrate small tumors and its physical half-life of 6.734 days is long enough for $$^{177}$$Lu-labeled antibodies to accumulate to tumor sites. In addition, real time imaging of biodistribution can be done by using the $$^{177}$$Lu, because the energy of $$gamma$$-rays (113 keV and 208 keV) emitted from $$^{177}$$Lu is particularly suitable for imaging by single photon emission computed tomography. We can produce $$^{177}$$Lu by the $$^{176}$$Lu (n,$$gamma$$) $$^{177}$$Lu process and the $$^{176}$$Yb(n,$$gamma$$) $$^{177}$$Yb (T$$_{1/2}$$=1.911 h)$$rightarrow$$$$^{177}$$Lu process. In the field of radioimmunotherapy using labeled monoclonal antibodies, to enhance the effect of therapy, no-carrier-added (nca) $$^{177}$$Lu produced in the $$^{176}$$Yb(n,$$gamma$$) $$^{177}$$Yb (T$$_{1/2}$$=1.911 h) $$rightarrow$$$$^{177}$$Lu process with high specific radioactivity are required. Therefore, in the present paper, production of highly-purified nca $$^{177}$$Lu from macroscopic amounts of the ytterbium target is developed.

使用言語

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English

掲載資料名

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巻

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号

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ページ数

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発行年月

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発表会議名

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2010 International Chemical Congress of Pacific Basin Societies (PACIFICHEM 2010)

開催年月

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2010/12

開催都市

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Honolulu

開催国

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U.S.A.

キーワード

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no keyword

特許データ

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PDF

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論文URL

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研究データの公開先DOI

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使用施設

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RI製造棟  

広報プレスリリース

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論文解説記事
(成果普及情報誌)

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受委託・共同研究相手機関

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群馬大学

Access

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- Accesses

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