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The Radiosesitization effect of Hsp90 inhibitor 17AAG in ${it in vivo}$ model

Takahashi, Momoko; Noguchi, Miho; Hirakawa, Hirokazu*; Okayasu, Ryuichi*

Ionizing radiation has been widely used as a tool for tumor treatment. However, there are still difficulties to treat the solid tumor with only irradiation. Several studies have been shown that the combination therapy using both X-irradiation and antitumor drug is more effective to tumor compared with X-irradiation only. Previously Noguchi et al. showed the Hsp90 inhibitor 17AAG induced tumor cell death effectively with X-irradiation. Hsp90 is the enzymes activated by cellular stress and activates several tumor-related genes. To clarify whether or not the combination therapy of carbon ion beam and 17AAG is effective to solid tumors, we tested the growth of solid tumor with the combination of X-irradiation and 17AAG ${it in vivo}$ and compared the results from ${it in vitro}$ study.



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