Characterization of Xenopus laevis thrombocytic cells stimulated by thrombopoietin in liquid culture

Tahara, Ayaka*; Tanizaki, Yuta*; Okui, Takehito*; Meguro, Mizue; Kinoshita, Sayaka*; Maekawa, Shun*; Yamauchi, Motoki*; Shimoji, Miyako*; Ishida, Takako*; Nagai, Yutaka*; Kuroki, Ryota; Kato, Takashi

Most vertebrates have nucleated thrombocytes instead of platelets or megakaryocytes. African clawed frog Xenopus laevis, produces such thrombocytes in liver and spleen. We made a recombinant X.laevis thrombopoietin-like polypeptide (xlTPO) and found it had colony-forming activity in semi-solid assays of liver and spleen. Further studies focused on characterizing the thrombocytes and thrombocytic progenitors were performed to confirm whether xlTPO is a functional ortholog of mammalian TPO.

Language	:	English
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Meeting title	:	International Society of Experimental Hematology (ISEH) 2010
Held date	:	2010/09
Location (city)	:	Melbourne
Location (country)	:	Australia
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Keywords	:	no keyword
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Cooperating Institute	:	早稲田大学

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Registration No. : BB20110414
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