Measurement of DNA double-strand break yield in human cancer cells by high-current, short-duration bunches of laser-accelerated protons

高電流・短時間パルスレーザー駆動陽子線によるヒトがん細胞のDNAに本鎖切断収量の測定

余語 覚文; 佐藤 克俊; 錦野 将元; 前田 拓也*; 榊 泰直; 堀 利彦*; 小倉 浩一; 西内 満美子; 手島 昭樹*; 西村 博明*; 近藤 公伯; Bolton, P.; 河西 俊一*

Yogo, Akifumi; Sato, Katsutoshi; Nishikino, Masaharu; Maeda, Takuya*; Sakaki, Hironao; Hori, Toshihiko*; Ogura, Koichi; Nishiuchi, Mamiko; Teshima, Teruki*; Nishimura, Hiroaki*; Kondo, Kiminori; Bolton, P.; Kawanishi, Shunichi*

To investigate the radiobiological effects of high dose rates that are attributed to high current, short bunch beam generation with laser-dreven ion acceleration, we have developed an experimental setup that uses laser-accelerated protons. human lung cancer cells: A549 pulmonary adenocarcinoma are irradiated with a laser-accelerated proton bunches with a duration of s and flux of cms, amounting to single bunch absorbed dose at the 1 Gy level. The double-strand break (DSB) yield in cell DNA is analyzed for the laser-accelerated proton beam at an average LET of 41 keV/m.