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Report No.

Effect of oxidative DNA damage on radiation-induced mutagenesis in ${it Arabidopsis thaliana}$

Yoshihara, Ryohei; Hase, Yoshihiro; Nozawa, Shigeki; Narumi, Issei; Takimoto, Koichi*; Hidema, Jun*; Sakamoto, Ayako

We analyzed $$gamma$$-ray-induced mutation spectrum in Arabidopsis seedling to investigate the effect of oxidative DNA damage on mutagenesis. Moreover, to evaluate the effect of nucleotide pool sanitization system on $$gamma$$-ray-induced mutations, we analyzed a mutant deficient in the Arabidopsis ${it NUDT1}$ gene that is a homologue of ${it mutT}$. The $$gamma$$-ray sensitivity of the ${it NUDT1}$ mutant was slightly higher, but not statistically significant, than that of wild type plant. However, the mutation spectra induced by $$gamma$$-rays were different between the wild type and ${it NUDT1}$ plants. From these results, it was suggested that the ${it NUDT1}$ deficiency obviously affects on the mutagenesis but not the plant growth following $$gamma$$-irradiation.



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