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Fundamental study on molecular mechanism underlying repair of heavy-ion induced DNA damage in the ${it Saccharomyces cerevisiae}$

Matsuo, Yoichiro*; Izumi, Yoshinobu*; Hase, Yoshihiro; Sakamoto, Ayako; Nozawa, Shigeki; Narumi, Issei; Shimizu, Kikuo*

We have been studying ion-beam induced mutations in the budding yeast as a model of eukaryote cell. Yeast cells were irradiated with 220 MeV carbon ions with 107 keV/$$mu$$m LET. The survival rates following irradiation were determined on the basis of colony-forming ability. ${it rad50}$ and ${it rad52}$ strains showed hyper sensitivity, while the ${it ogg1}$ and ${it msh2}$ strains showed relatively lower sensitivity to the carbon ion irradiation. The expression of ${it RAD50}$ gene was up-regulated following carbon ion irradiation but not $$gamma$$ rays. This difference may result from the repair pathway that operates in mutant strains.

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