検索対象:     
報告書番号:
※ 半角英数字
 年 ~ 
 年

国産化$$^{99}$$Mo/$$^{rm 99m}$$Tcの医療運用に向けての課題; 加速器中性子利用$$^{99}$$Mo/$$^{rm 99m}$$Tc生成による$$^{99}$$Mo国産化開発研究

Problems in clinical practice of domestic supply of $$^{99}$$Mo/$$^{rm 99m}$$Tc; Development of $$^{99}$$Mo/$$^{rm 99m}$$Tc production using accelerator neutrons

永井 泰樹

Nagai, Yasuki

高強度重陽子を用いて得られる加速器中性子を$$^{100}$$Moに照射して$$^{99}$$Moを生成する方法は我が国独自の生成法であり、$$^{99}$$Moの国内需要の20%程度を供給できると期待される。実際、加速器中性子で生成された$$^{99}$$Moは不要RIの含有量が少なく、昇華法で得た$$^{rm 99m}$$Tcは放射性医薬品に要求される核純度を持ち、医薬品に対し高い標識率を持つことが示された。その結果、$$^{99}$$Moの国内供給の安定化への寄与に加え、$$^{99}$$Moの海外の需要増加が見込める中で、原子力を有しない国への展開が期待される。

A new method was proposed to produce $$^{99}$$Mo by the $$^{100}$$Mo(n,2n)$$^{99}$$Mo reaction using intense neutrons from an accelerator by us. About 20% of the demand of $$^{99}$$Mo in Japan could be obtained constantly by the proposed method. In fact, we have shown that the produced $$^{99}$$Mo contained very little RI impurity and the radionuclide purity of $$^{rm 99m}$$Tc separated from $$^{99}$$Mo by sublimation and the labeling efficiency of $$^{rm 99m}$$Tc-MDP exceed the United States Pharmacopeia requirements for a fission product, $$^{99}$$Mo. We expect that the present $$^{99}$$Mo production method will be accepted worldwide to ensure the constant domestic supply of $$^{99}$$Mo.

Access

:

- Accesses

InCites™

:

Altmetrics

:

[CLARIVATE ANALYTICS], [WEB OF SCIENCE], [HIGHLY CITED PAPER & CUP LOGO] and [HOT PAPER & FIRE LOGO] are trademarks of Clarivate Analytics, and/or its affiliated company or companies, and used herein by permission and/or license.