Mathematical model of cell-cycle dependency of chromosomal aberration by DSB

Ouchi, Noriyuki

Chromatin fiber is the container of DNA in Cell nucleus, its structure is changed drastically depending on the cell cycle, and make 10000 times condensed structure as known as chromosome at metaphase. Here we will show the simulation results of the mathematical model of chromosome/chromatin broken ends movement which will be produced by DSB, not only its dynamics but the dependency of cell cycle, and investigate the damage effectiveness on the whole system.

Language	:	Japanese
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Meeting title	:	日本放射線影響学会第55回大会
Held date	:	2012/09
Location (city)	:	仙台
Location (country)	:	日本
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Registration No. : BB20121597
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