Production and utilization of astatine radioisotopes using Li ion beams

Nishinaka, Ichiro; Yokoyama, Akihiko*; Washiyama, Koshin*; Amano, Ryohei*; Maeda, Eita*; Taniguchi, Takumi*; Murakami, Kento*; Watanabe, Shigeki; Suzuki, Hiroyuki; Ishioka, Noriko; Hashimoto, Kazuyuki; Makii, Hiroyuki   

In general, an -emitter At which is a prospective candidate for utilization in targeted alpha radiotherapy is produced through the Bi(He, 2n)At reaction. In contrast, our project is focusing on the production in the Bi(Li, 5n)Rn reaction. This enables us to supply At in a Rn/At generator system. The daughter At (7.2 h half-life) is extracted from the parent Rn (14h), expanding time-frame for transportation and use of At. To use astatine and iodine radioisotopes in our project, the excitation functions of Bi(Li, xn)Rn, Pb(Li, xn)At and Sn(Li, xn)I reactions have been measured. In addition to that, separation techniques have been developed. We report not only on the production and separation of astatine and iodine radioisotopes in the reactions but also on the utilization of those radioisotopes.