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Report No.

Complexation of lutetium-177 with bifunctional chelators in the presence of Mg, Cu, and Yb

Watanabe, Satoshi; Hashimoto, Kazuyuki; Ishioka, Noriko

As part of basic studies for the production of $$^{177}$$Lu capable of labeling of $$^{177}$$Lu-1,4,7,10-tetraazacyclododecan-N,N',N'',N'''-tetraacetic acid (DOTA)-antibody, $$^{177}$$Lu complexation of DOTA and diethylenetriamine-N,N,N',N'',N''-pentaacetic acid (DTPA) was investigated in the presence of competing metals: Mg, Cu, and Yb in addition to Ca, Fe, and Zn. The inhibition of $$^{177}$$Lu complexation by the competing metals was in the order of Mg, Ca $$<$$ Fe $$<$$ Yb $$<$$ Cu, Zn and Mg, Ca $$<$$ Zn $$<$$ Fe $$<$$ Cu $$<$$ Yb with DOTA and DTPA, respectively. Consequently, the elimination of Mg and Ca from the $$^{177}$$Lu final solution produced was not found to be necessary, while the elimination of Cu, Fe, Zn and Yb from the $$^{177}$$Lu final solution was found to be necessary. On the basis of the knowledge obtained, the method of elimination of the competing metals will be developed.



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