Role of secondary electrons for radiation complex DNA damage

Kai, Takeshi   ; Yonetani, Yoshiteru*; Yokoya, Akinari*

Deeply study for radiation DNA damage is very important to understand initial factors for mutation and cancer inductions. Recently, photolysis techniques have revealed that pre-hydrated electrons can induce DNA damage through dissociative electron transfer (DET). The contributions to DNA damage by DET have not been fully investigated in previous theoretical studies. Thus a dynamic Monte Carlo code (DMCC) was developed to consider effect of the DET. From the analysis used by the DMCC, we revealed that pre-hydrated electrons contribute to formation of complex DNA damage. Thus we also have developed a newly calculation method combined with the DMCC and molecular dynamics method. The method makes it possible to predict formation of pre-hydrated electrons. In this presentation, we will report current states of development for the newly method.