Comparative of suppressive effects by low-dose radiation and related-medicine using machine learning

Kanzaki, Norie   ; Kataoka, Takahiro*; Kobashi, Yusuke*; Ishida, Tsuyoshi*; Yunoki, Yuto*; Sakoda, Akihiro   ; Ishimori, Yuu  ; Yamaoka, Kiyonori*

We have suggested that low-dose radiation increases anti-oxidative function and inhibits various oxidative stress-related diseases. On the other hand, there are some reports about the extraction of some plants which inhibit similar diseases. In this research, we collected and analyzed the reports for comprehensive comparison. For example, we found that the effects of radon 2000 Bq/m inhalation for 24 hours (low-dose irradiation) or taraxeren-3-one (the extraction from diospyros maritima) 20 mg/kg bodyweight administration were similar with the effects of indomethacin 10 mg/kg bodyweight administration regarding carrageenan-induced paw edema. Our results have a limitation of small dataset but are useful for future research about oxidative stress.