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A New Standard DNA Damage (SDD) data format

新しい標準DNA損傷データフォーマットの提案

Schuemann, J.*; McNamara, A. L.*; Warmenhoven, J. W.*; Henthorn, N. T.*; Kirkby, K.*; Merchant, M. J.*; Ingram, S.*; Paganetti, H.*; Held, K. D.*; Ramos-Mendez, J.*; Faddegon, B.*; Perl, J.*; Goodhead, D. T.*; Plante, I.*; Rabus, H.*; Nettelbeck, H.*; Friedland, W.*; Kundr$'a$t, P.*; Ottolenghi, A.*; Baiocco, G.*; Barbieri, S.*; Dingfelder, M.*; Incerti, S.*; Villagrasa, C.*; Bueno, M.*; Bernal, M. A.*; Guatelli, S.*; Sakata, D.*; Brown, J. M. C.*; Francis, Z.*; Kyriakou, I.*; Lampe, N.*; Ballarini, F.*; Carante, M. P.*; Dav$'i$dkov$'a$, M.*; $v{S}$t$v{e}$p$'a$n, V.*; Jia, X.*; Cucinotta, F. A.*; Schulte, R.*; Stewart, R. D.*; Carlson, D. J.*; Galer, S.*; Kuncic, Z.*; Lacombe, S.*; Milligan, J.*; Cho, S. H.*; Sawakuchi, G.*; 稲庭 拓*; 佐藤 達彦; Li, W.*; Solov'yov, A. V.*; Surdutovich, E.*; Durante, M.*; Prise, K. M.*; McMahon, S. J.*

Schuemann, J.*; McNamara, A. L.*; Warmenhoven, J. W.*; Henthorn, N. T.*; Kirkby, K.*; Merchant, M. J.*; Ingram, S.*; Paganetti, H.*; Held, K. D.*; Ramos-Mendez, J.*; Faddegon, B.*; Perl, J.*; Goodhead, D. T.*; Plante, I.*; Rabus, H.*; Nettelbeck, H.*; Friedland, W.*; Kundr$'a$t, P.*; Ottolenghi, A.*; Baiocco, G.*; Barbieri, S.*; Dingfelder, M.*; Incerti, S.*; Villagrasa, C.*; Bueno, M.*; Bernal, M. A.*; Guatelli, S.*; Sakata, D.*; Brown, J. M. C.*; Francis, Z.*; Kyriakou, I.*; Lampe, N.*; Ballarini, F.*; Carante, M. P.*; Dav$'i$dkov$'a$, M.*; $v{S}$t$v{e}$p$'a$n, V.*; Jia, X.*; Cucinotta, F. A.*; Schulte, R.*; Stewart, R. D.*; Carlson, D. J.*; Galer, S.*; Kuncic, Z.*; Lacombe, S.*; Milligan, J.*; Cho, S. H.*; Sawakuchi, G.*; Inaniwa, Taku*; Sato, Tatsuhiko; Li, W.*; Solov'yov, A. V.*; Surdutovich, E.*; Durante, M.*; Prise, K. M.*; McMahon, S. J.*

DNA損傷には様々なタイプがあり、異なった生物学的効果を引き起こす。過去数10年間、放射線照射によるDNA損傷の生成やそれらが引き起こす生物効果のシミュレーションが行われてきたが、各研究者が独自のデータフォーマットを用いて解析していたため、相互比較を行うことができなかった。そこで、本論文では、新しい標準DNA損傷データフォーマットを提案し、モデル間の相互比較を可能とする。これにより、放射線照射によるDNA損傷のメカニズム解明や放射線影響シミュレーション研究の活性化を図る。

We propose a new Standard DNA Damage (SDD) data format to unify the interface between the simulation of damage induction in DNA and the biological modelling of DNA repair processes, and introduce the effect of the environment (molecular oxygen or other compounds) as a flexible parameter. Such a standard greatly facilitates inter-model comparisons, providing an ideal environment to tease out model assumptions and identify persistent, underlying mechanisms. Through inter-model comparisons, this unified standard has the potential to greatly advance our understanding of the underlying mechanisms of radiation-induced DNA damage and the resulting observable biological effects when radiation parameters and/or environmental conditions change.

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