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Report No.

A New Standard DNA Damage (SDD) data format

Schuemann, J.*; McNamara, A. L.*; Warmenhoven, J. W.*; Henthorn, N. T.*; Kirkby, K.*; Merchant, M. J.*; Ingram, S.*; Paganetti, H.*; Held, K. D.*; Ramos-Mendez, J.*; Faddegon, B.*; Perl, J.*; Goodhead, D. T.*; Plante, I.*; Rabus, H.*; Nettelbeck, H.*; Friedland, W.*; Kundr$'a$t, P.*; Ottolenghi, A.*; Baiocco, G.*; Barbieri, S.*; Dingfelder, M.*; Incerti, S.*; Villagrasa, C.*; Bueno, M.*; Bernal, M. A.*; Guatelli, S.*; Sakata, D.*; Brown, J. M. C.*; Francis, Z.*; Kyriakou, I.*; Lampe, N.*; Ballarini, F.*; Carante, M. P.*; Dav$'i$dkov$'a$, M.*; $v{S}$t$v{e}$p$'a$n, V.*; Jia, X.*; Cucinotta, F. A.*; Schulte, R.*; Stewart, R. D.*; Carlson, D. J.*; Galer, S.*; Kuncic, Z.*; Lacombe, S.*; Milligan, J.*; Cho, S. H.*; Sawakuchi, G.*; Inaniwa, Taku*; Sato, Tatsuhiko  ; Li, W.*; Solov'yov, A. V.*; Surdutovich, E.*; Durante, M.*; Prise, K. M.*; McMahon, S. J.*

We propose a new Standard DNA Damage (SDD) data format to unify the interface between the simulation of damage induction in DNA and the biological modelling of DNA repair processes, and introduce the effect of the environment (molecular oxygen or other compounds) as a flexible parameter. Such a standard greatly facilitates inter-model comparisons, providing an ideal environment to tease out model assumptions and identify persistent, underlying mechanisms. Through inter-model comparisons, this unified standard has the potential to greatly advance our understanding of the underlying mechanisms of radiation-induced DNA damage and the resulting observable biological effects when radiation parameters and/or environmental conditions change.



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