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Production and synthesis of a novel $$^{191}$$Pt-labeled platinum complex and evaluation of its biodistribution in healthy mice

新規$$^{191}$$Pt標識白金錯体の製作・合成と健康マウスにおける生体内分布の評価

面川 真里奈*; 木村 寛之*; 初川 雄一*; 河嶋 秀和*; 塚田 和明  ; 屋木 祐介*; 内藤 行基*; 安井 裕之*

Omokawa, Marina*; Kimura, Hiroyuki*; Hatsukawa, Yuichi*; Kawashima, Hidekazu*; Tsukada, Kazuaki; Yagi, Yusuke*; Naito, Yuki*; Yasui, Hiroyuki*

$$^{191}$$Pt was produced via the (n,2n) reaction induced by accelerator neutrons. [$$^{191}$$Pt]FGC-Pt was obtained through the accelerator neutron irradiation of FGC-Pt and K$$_{2}$$PtCl$$_{4}$$. Highly purified [$$^{191}$$Pt]FGC-Pt was obtained using the latter method, which suggests that the synthetic method using a $$^{191}$$Pt-labeled platinum reagent is suitable for the radioactivation of platinum complexes. We also investigated whether a significant correlation existed between the biodistribution of FGC-Pt and [$$^{191}$$Pt]FGC-Pt in healthy mice 24 h after tail vein administration. These results suggest that $$^{191}$$Pt-labeled compounds, synthesized using radioactive platinum reagents, can be used to confirm the biodistribution of platinum compounds. Our study on the biodistribution of [$$^{191}$$Pt]FGC-Pt is expected to contribute to the development of novel platinum-based drugs in the future.

発表言語

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English

掲載資料名

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Bioorganic & Medicinal Chemistry

巻

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97

号

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ページ数

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p.117557_1 - 117557_6

発行年月

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2024/01

発表会議名

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開催年月

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開催都市

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開催国

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キーワード

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Pt-191ラベル錯体合成; 薬剤合成; 体内分布

特許データ

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PDF

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論文URL

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https://doi.org/10.1016/j.bmc.2023.117557

研究データの公開先DOI

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本成果にかかわる研究データのリンクです。

使用施設

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広報プレスリリース

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論文解説
(JAEA R&D Navigator)

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受委託・共同研究相手機関

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量研機構; 京都薬科大学

Access

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- Accesses

InCites™

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パーセンタイル：11.80

分野：Biochemistry & Molecular Biology

Altmetrics

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